2025-05-12T14:28:09-07:00 2024-12-31 990 2024-01-01 473425850 CANCER PREVENTION INITIATIVE INC CANC 8444374891 1722 Routh Street Suite 770 Dallas TX 75201 Theodora Ross President 8444374891 2025-05-12 1 2024 2025-03-06 01:10:19Z Theodora Ross 2555 N Pearl Street Unit 1802 Dallas TX 75201 1673681 0 X www.cancerpreventioninitiative.org X 2015 DE Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. 6 6 0 6 0 0 65 1604577 0 0 49520 69104 0 0 49585 1673681 53367 650000 0 0 0 0 0 30000 30066 21027 23827 74394 703827 -24809 969854 821212 2225249 145996 580179 675216 1645070 Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. CPI uses its research, medical and pharmaceutical expertise to invest in first-rate science that will discover new strategies for preventing cancer. Our strategy is to support research on prevention of inherited cancers as a path towards elimination of all cancers. CPI acts as a facilitator to ensure that good ideas can find sufficient funding to turn them into therapeutic solutions such as drugs or vaccines to prevent cancer. CPI provides financial support, guidance and expertise throughout the research and development process to help researchers use the resources (donations) for the highest possible impact. 0 0 655880 650000 0 In 2024, Cancer Prevention Initiative (CPI) selected new projects to fund. We received more than 50 proposals pertaining to the therapeutic prevention of inherited cancer. In our selection, we expanded our research portfolio beyond BRCA1/2 mutated cancers and one of the new projects studies Lynch Syndrome. We reviewed applications covering all three strategic categories of research: Discovery research that expands the knowledge of early-pre-cancer stages and mechanisms of cancer initiation, development of early detection tests, and the development of chemo and/or immunotherapeutic agents. The volume of proposals indicates both the need for funding in this area and the enthusiasm of the research community to invest their discovery efforts in prevention. Also in 2024, CPI's ongoing research grant recipients have advanced towards greater understanding of preventing inherited cancers. Ongoing projects include Cleveland Clinic, where investigators seek to identify proteins uniquely and highly expressed in breast cancer of BRCA1 mutation carriers. Identification of these unique proteins is an important link for developing preventative vaccines. Also continuing is a project with Memorial Sloan Kettering Cancer Center to generate a robust cellular assay that would allow for the screening of hundreds of compounds to identify determinants of Loss of Heterozygosity (LoH) of BRCA genes. LoH is a major driver in cancer initiation, and discovery of compounds that cause LoH can be key for prevention discoveries. Other ongoing projects include Harvard's Beth Israel Deaconess Medical Center where they are working to identify cancer risk predictors in the reproductive epithelium in BRCA mutation carriers. CPI-funded scientist Dr. Joanne Kotsopoulos and her colleagues at University of Toronto concluded their project, in which they discovered FDA approved drugs that boost patients' sensitivity to PARP inhibitors, which are used in treatment of most cases of inherited ovarian and breast cancer. This work was published in iScience and has the potential to transform treatment of BRCA-mutation driven cancer. 0 0 0 Education and engagement programs: As we move closer to our goal of eradicating all cancers through preventative medicines, we believe that educating the public and raising awareness about inherited cancer syndromes will inspire more individuals to take proactive, life-saving preventive measures. One of the goals is to enhance the scientific reach of the organization and raise awareness on cancer prevention to a broader audience of patients, advocates and donors. Updates on scientific and medical research advances, recent clinical trials, and interviews with experts in cancer prevention are published on web-based platforms. 0 0 0 655880 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 X 6 6 0 0 0 0 0 0 0 1 0 0 0 1 1 1 1 1 1 0 0 0 CA CO CT FL GA IL KS NJ PA X Archer Accountancy Group 8444374891 531 Main Street No 833 El Segundo CA 90245 Theodora Ross President & Chief Scientific Officer 5 0 X X 0 0 0 Howard Janzen Board Chair; Chief Financial Officer 5 0.00 X X 0 0 0 Kirk Patrick Secretary, Trustee 0.5 0 X X 0 0 0 Jan Livingston-Mokhtari Trustee 0.5 0 X 0 0 0 Douglas Hager Trustee, Sr. Vice President, Project Management and Operations 10 0 X 0 0 0 Joi Morris Trustee 5 0 X 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1604577 0 1604577 0 69104 0 0 69104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1673681 0 0 69104 650000 650000 0 0 0 0 0 0 3560 3560 0 30000 30000 3500 3500 316 299 17 8724 5880 2844 3395 3395 2690 2690 Bank Charges 60 0 60 0 Fees and Licenses 903 0 903 0 Dues & Subscriptions 679 0 630 49 703827 655880 17881 30066 6759 833 3826 4500 0 0 0 0 0 0 0 0 0 0 0 0 1012 1063 804620 2217253 4995 1600 821212 2225249 955 0 145000 580000 0 0 0 0 0 0 0 0 0 0 0 41 179 145996 580179 X 263818 328570 411398 1316500 675216 1645070 821212 2225249 969854 0 0 0 0 0 X 0 1 X 1 0 X 480096 135 245219 65 1604578 2330093 480096 135 245219 65 1604578 2330093 400749 1929344 1695 16 11849 49519 69399 132478 0 0 0 0 0 0 0 0 2462571 0.78347 0.4192 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 Credit Card Payable 179 179 X 1673681 0 0 0 0 0 1673681 0 0 0 1673681 703827 0 0 0 0 0 703827 0 0 0 703827 Schedule D, Part X, Line 2 The Organization is exempt from federal income taxes under Section 501(c)(3) of the Internal Revenue Code. Unrelated business income, of which the Organization had no significant amounts for the year ended December 31, 2024, is subject to federal income taxes. Accordingly, there is no provision or liability for federal income taxes. The Organization is classified as an organization other than a private foundation. The Organization regularly assesses uncertain tax positions in each of the tax jurisdictions in which it has operations and accounts for the related financial statement implications. Uncertain tax benefits are reported using the two-step approach under which tax effects of a position are recognized only if it is "more likely than not" to be sustained and the amount of the tax benefit recognized is equal to the largest tax benefit that is greater than fifty percent likely of being realized upon ultimate settlement of the tax position. Determining the appropriate level of unrecognized tax benefits requires the Organization to exercise judgement regarding the uncertain application of tax law. The amount of unrecognized tax benefits is adjusted when information becomes available or when an event occurs indicating a change is appropriate. Future changes in unrecognized tax benefits requirement could have a material impact on the results of operations. The Organization is generally no longer subject to tax examinations relating to the US federal tax returns for three years prior to the last filing. X 1 Dynamic Development Strategies LLC 5100 Oak Mill Drive Fort Worth TX 76136 Dynamic Development worked with the CPI Board and team to develop a case statement and fundraising plan. 0 0 30000 -30000 0 30000 -30000 CA CO CT FL IL KS NJ PA 1 Dana Farber Cancer Institute 450 Brookline Avenue Boston MA 021155450 042263040 450000 0 The objective of this project is to identify aberrantly expressed age-related drivers of cancer in individuals with inherited cancer syndromes related to BRCA mutations. This project will help develop preventive measures such as vaccines targeting cancer-initiating progenitor cells. University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390 752556007 200000 0 Scientific and administrative oversight of all Cancer Prevention Initiative programs. 2 0 Schedule I, Part I, Line 2 CPI conducts independent scientific peer review on all research applications before making grant award decisions. The Organization requires regular financial and narrative reports for all grant recipients on the use of grant funds and the research conducted with the funds. Every grant contract contains specific research milestones and deliverables that are tracked throughout the research process. CPI's reporting requirements include reports on all research results and achievement of scheduled milestones. Annual financial reports must provide details regarding monies spent in comparison to the grant budget. Ongoing research payments are only authorized when satisfactory research reports are received and approved by the scientific team. Form 990, Part VI, Section A, Line 8b Governing body has no committees with authority to act on behalf of the board. Form 990, Part VI, Section B, Line 11b All members of the governing body receive a copy of the 990 prior to filing, with the opportunity for input and questions. Form 990, Part VI, Section B, Line 12c The Board of Trustees annually reviews the Conflict of Interest policy and each covered person is annually required to sign a statement that discloses all potential conflicts of interest and affirms that such person: 1. Has received a copy of the Conflict of Interest policy; 2. Has read and understands the Conflict of Interest policy; 3. Has agreed to comply with the Conflict of Interest policy; 4. Understands that CPI is a charitable organization and that in order to maintain its federal tax exemption and the trust of the public it must diligently avoid conflicts of interest or the appearance of any conflict of interest and engage primarily in activities that accomplish one or more of its tax-exempt purposes. Form 990, Part VI, Section C, Line 19 CPI complies with IRC Section 6104 in regard to public disclosure. As such, our annual information returns, Conflict of Interest policy, audited financial reports, and governing documents are available for public inspection upon request.