2025-03-12T11:22:52-04:00 2024-12-31 474306215 Mullins PC 7625 Wisconsin Ave Suite 317 Bethesda MD 20814 990 2024-01-01 464309387 Usher 1F Collaborative Inc % Melissa Chaikof USHE 3392212743 321 Walnut Street STE 228 Newtonville MA 02460 MELISSA CHAIKOF Chair and Trustee 3392212743 2025-03-11 true true JOHN MULLINS P01429307 2027706371 2025-03-12 2024 2025-03-06 01:10:19Z Melissa Chaikof 321 Walnut Street STE 228 Newtonville MA 02460 940981 false X www.usher1f.org X 2013 MA To fund medical research to find an effective treatment to save or restore the vision of those affected with Usher Syndrome Type 1F. 10 10 1 23 0 0 429829 623437 0 13030 16704 209249 446533 845716 432142 671155 0 72178 76942 0 154180 141944 123002 646264 871099 -199731 -25383 810900 781549 7699 3731 803201 777818 To fund medical research to find an effective treatment to save or restore the vision of those affected with Usher Syndrome Type 1F. false false 678470 671155 2024 Grants to Research Labs:Harvard Medical School, David Corey Lab: $291,155The Salk Institute, Samuel Pfaff Lab: $150,000University of Oregon Institute of Neuroscience, Monte Westerfield Lab: $30,0002024 Grant for year 3 of RUSH1F, 4-year natural history study in partnership with Foundation Fighting Blindness: $200,000Total grants awarded in 2024: $671,155 Key Research advances realized in 2024: Harvard mini-gene in preclinical testing produced stunning results in nonhuman primate retinas. Harvard team published the following papers in peer-reviewed jounals: o PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models o Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins Funded partnership between the Corey Lab at Harvard Medical School and the Pfaff Lab atThe Salk Institute to complete development of dual vector gene therapy using proprietary RNA End Joining (REJ) approach and begin testing of this gene therapy on mouse model at Harvard 678470 true true false false false false false false false false false false false false false true true false false false false false false false true false false true false false false false false false false false false false false false false false false false false false false true 1 0 true 1 true false false false false false false false false false false false false X 10 10 true false false false false false false true true false false true false false false false false false MA X The Organization 3392212743 321 Walnut Street 228 Newtonville MA 02460 X Joshua Cohen Trustee 2.00 0.00 X 0 0 0 Rachel Root Trustee 2.00 0.00 X 0 0 0 Julian Seewald Trustee 2.00 0.00 X 0 0 0 Sari L Springer Trustee 2.00 0.00 X 0 0 0 Heather Rosenstein Trustee 2.00 0.00 X 0 0 0 Eric Halper Trustee 2.00 0.00 X 0 0 0 Margi Levitt Trustee 2.00 0.00 X 0 0 0 Dorie Shapiro Trustee 2.00 0.00 X 0 0 0 Melissa Chaikof Chair and Trustee 40.00 0.00 X X 0 0 0 Elliot Chaikof Vice Chair and Trustee 2.00 0.00 X X 0 0 0 Frank Gentile Treasurer and Trustee 2.00 0.00 X X 0 0 0 Jared Root Secretary and Trustee 4.00 0.00 X X 0 0 0 0 0 0 0 false false false 623437 623437 13030 13030 304440 95265 209175 209175 Other 900099 74 74 74 845716 74 0 222205 X 671155 671155 69285 69285 2079 2079 231 231 5347 5347 8874 8874 76811 836 11696 64279 7262 6461 801 22474 18 13949 8507 2484 2484 4482 3815 667 Dues and Subscriptions 615 115 500 871099 678470 38449 154180 47815 15521 753285 660358 9800 105670 810900 781549 7699 3731 7699 3731 X 799201 668148 4000 109670 803201 777818 810900 781549 -25383 0 X false true X true false X 1224057 596676 1081791 429829 623437 3955790 1224057 596676 1081791 429829 623437 3955790 93871 126821 121813 95480 163602 601587 93871 126821 121813 95480 163602 601587 3354203 9872 1126 1187 5955 13030 31170 9872 1126 1187 5955 13030 31170 1233929 597802 1082978 435784 636467 3986960 0.84130 0.86360 0.01000 0.01000 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED X 845716 845716 845716 871099 871099 871099 Part X, Line 2-Text in footnote regarding FIN 48 (ASC 740) The accounting standard on accounting for uncertainty in income taxes addresses the determination of whether tax benefits claimed or expected to be claimed on a tax return should be recorded in the financial statements. Under that guidance, The Collaborative may recognize the tax benefit from an uncertain tax position only if it is more likely than not that the tax position will be sustained on examination by taxing authorities based on the technical merits of the position.The tax benefits recognized in the financial statements from such a position are measured based on the largest benefit that has a greater than 50% likelihood ofbeing realized upon ultimate settlement. There were no unrecognized tax benefits identified or recorded as liabilities at year-end. The Collaboratives policy would be to recognize interest and penalties, if any, on tax positions related to its unrecognized tax benefits in income tax expense in the financial statements. No interest and penalties were assessed or recorded during the year. Fundraising 304440 304440 95265 304440 304440 95265 95265 209175 true Harvard University 1033 Massachusetts Ave Cambridge MA 02138 042103580 501c3 291155 University of Oregon Foundation 1720 E 13th Ave Eugene OR 97403 936015767 501c3 30000 The Salk Institute 10010 N Torrey Pines Road La Jolla CA 920371002 311678679 501c3 150000 Foundation Fighting Blindness 6925 Oakland Mills Road Columbia MD 21045 237135845 501c3 200000 4 Monitoring procedures (Part I, line 2) The Organization receives written updates from the grant recipients every six months or as needed if there are important progress updates. The Organization also speaks to the funded researchers periodically to receive updated either via phone or email. Officer directors etc family relationship Part VI line 2 Melissa Chaikof is married to Elliot Chaikof. Rachel Root is married to Jared Root. Sari Springer is Elliot Chaikofs sister. Form 990 governing body review Part VI line 11 The 990 is reviewed by an officer of The Board prior to filing. Governing documents etc available to public Part VI line 19 The Organization will provide document copies upon request. Explanation of other changes in net assets or fund balances Part XI line 9 Prior Period Adjustment of -$292,083. This adjustment was needed to reconcile the ending balance on the 2022 990 to the beginning balance on the 2023 Audited Financial Statements. List of other fees for services expenses Part IX line 11g Professional Services: $60,000Information Technology: $11,689Other: $5,122