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        <PersonNm>Yang Shi</PersonNm>
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      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>Alexander Borissov</PersonNm>
        <TitleTxt>SEC. TO BOARD, INTERNAL AUDIT</TitleTxt>
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        <PersonNm>Gerd Ritter</PersonNm>
        <TitleTxt>TECHNOLOGY DEVELOPMENT MANAGER</TitleTxt>
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        <PersonNm>Xing Chen</PersonNm>
        <TitleTxt>Director (From 7/24)</TitleTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule J, Part I, Line 3</FormAndLineReferenceDesc>
        <ExplanationTxt>Edward A. McDermott Jr. was employed until June 30, 2024 by the Ludwig Group, Inc. which provides management and administrative services to the Ludwig Institute for Cancer Research Ltd, LICR Fund, Inc., and other organizations. The Ludwig Institute is invoiced by the Ludwig Group, Inc. for the provision of services based on the time records maintained by the Ludwig Group, Inc. The total level of compensation for Edward A. McDermott Jr. which was paid by the Ludwig Group, Inc. under an employment agreement, was set and approved by the compensation committee of the Ludwig Institute. In setting the level of compensation, the Ludwig Institute's compensation committee arranges for an independent compensation survey.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule J, Part I, Line 4a</FormAndLineReferenceDesc>
        <ExplanationTxt>Michael Macaranas received severance payment of $208,575 in 2024. This amount is included in Schedule J, Part II, Column (B)(iii).</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule J, Part I, Line 4b</FormAndLineReferenceDesc>
        <ExplanationTxt>Edward A. McDermott Jr. participated in a supplemental non qualified retirement plan maintained by the Ludwig Group, Inc., a related organization of the Institute. The purpose of the Ludwig Group, Inc.'s supplemental pension plan is to provide certain supplemental benefits to certain select management or highly compensated employees who are participants in the employee pension plan of the Ludwig Group, Inc. All benefits payable under the plan, which is intended to constitute both an unfunded excess benefit plan under section 3(36) of title I of the employee retirement income security act of 1974, as amended, ("ERISA"), and a non qualified, unfunded deferred compensation plan for a select group of management or highly compensated employees under ERISA, are payable from the general assets of the Ludwig Group, Inc. The Ludwig Group, Inc. may establish and fund a trust in order to aid it in providing benefits due under the plan. Within the amount disclosed on Part VII, Section A, Line 1a, Column F, USD 21,621 is attributable to this plan for Edward A. McDermott Jr.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule J, Part II, Column B</FormAndLineReferenceDesc>
        <ExplanationTxt>Column (B) includes compensation paid outside the U.S. to non-U.S. persons for which no Form W-2 or 1099-MISC has been issued.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part III - Statement of program service accomplishments</FormAndLineReferenceDesc>
        <ExplanationTxt>LINE 3 - INSTITUTE SPONSORED CLINICAL TRIALS - DISCONTINUED THE DECISION TO WIND DOWN THE IN-HOUSE CLINICAL TRIALS MANAGEMENT TEAM IN NEW YORK WAS TAKEN IN 2018. BETWEEN 2019 AND 2023, NO NEW INSTITUTE SPONSORED CLINICAL TRIALS WERE STARTED AND ONGOING INSTITUTE SPONSORED CLINICAL TRIALS WERE CONTINUED UNTIL TERMINATION OF THE RESPECTIVE STUDIES WHICH WAS ACCOMPANIED BY A DECREASE OF COSTS DURING THESE YEARS. IN 2024, THE WIND-DOWN OF THE IN-HOUSE CLINICAL TRIALS MANAGEMENT TEAM, AS NOTED IN PREVIOUS RETURNS OF THE 990, CAN BE REGARDED AS COMPLETED.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part IV - Checklist of required schedules</FormAndLineReferenceDesc>
        <ExplanationTxt>Line 12A and Part XII - Financial statements and reporting, Line 1 The Ludwig Institute prepared consolidated financial statements in accordance with Swiss GAAP FER. The Ludwig Institute prepared statutory financial statements in accordance with the Swiss Code of Obligations. The Ludwig Institute prepared branch financial statements in accordance with the Swiss Code of Obligations for the following branches: Oxford (United Kingdom) and San Diego (United States) for the last time due to final closure of the branch. The submitted return 990 is based on the statutory financial statements in accordance with the Swiss code of Obligations. The following accounting principles apply: - Contributions are accounted for on the modified cash basis - Interest is accounted for on the accrual basis - External funding received from any outside source, whether of a cash or a non-cash nature is recorded in the Ludwig Institute's books of account on receipt. External funding received is taken to income when the corresponding expenditure is incurred. Any unspent income is deferred to future accounting periods. External funding pledged, but not received where expenditure has incurred, is taken into account as income and is accounted for as a grants receivable pending receipt. - License fees and royalties are accounted for on the modified cash basis. - Acquisition costs for research equipment, costs for leasehold improvements and costs for other assets are fully expensed in the year of acquisition. The Ludwig Institute maintains accounting ledgers for the head office / administration and the research locations of Oxford and San Diego. Accounting ledgers are maintained in USD. When any expenditure / income or balance sheet transactions are recorded in the accounts, a non-USD currency is converted into USD reporting currency using the monthly exchange rate of the transaction month as published by the Swiss federal tax administration.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Governing body and management, Line 2 Dr. Jonathan Skipper, officer of the Ludwig Institute for Cancer Research Ltd, also serves as officers and board members of Ludwig Technologies, Inc. Edward A. McDermott Jr., Director and Officer, up to June 30, of the Ludwig Institute for Cancer Research LTD also served as officers and board members of Ludwig Technologies, Inc up to June 30. Each of the members of the board of directors of the Ludwig Institute is also a member of the board of directors of the LICR Fund, Inc.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Governing body and management, Line 3 The Ludwig Group, Inc., a 100% subsidiary of the Ludwig Institute for Cancer Research Ltd, provides management and administrative services to the Ludwig Institute and related organizations, including personnel services and related facilities and equipment support, under formal service agreements with them. Edward A. McDermott Jr, director and president, up to June 30, of the Ludwig Institute, was employed and compensated by the Ludwig Group, Inc. His compensation listed on the form 990, part VII was paid by the Ludwig Group, Inc. The Institute's share of Edward A. McDermott Jr's services were billed to the Ludwig Institute by The Ludwig Group, Inc.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Governing body and management, Line 6 The Ludwig Institute is organized as a Swiss not-for-profit organization. 49 of the shares are held by the trustees of the LICR Charitable trust, a Bermuda trust recognized by the IRS as an exempt supporting organization of the Ludwig Institute under section 501(c)(3) and 509(a)(3) of the Internal Revenue Code, whose primary purpose is to administer, devote and apply its assets to further the charitable purposes of the Ludwig Institute. Pursuant to the provisions of the Ludwig Institute's statutes, the members of the board of directors are no longer required to be shareholders. Four of the trustees of the LICR Charitable Trust are members of the Institute board of directors. One of the four trustees of the LICR Charitable Trust was also an officer of the Ludwig Institute until June 30. One share is held by the Swiss confederation.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, Management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Governing body and management, Line 7a The statutes of the Ludwig Institute confer on its shareholders the authority to elect and remove members of the board of directors and participate in proceedings, deliberations elections and votes at shareholder meetings. The shares do not confer proprietary rights or any entitlement to any share of the Ludwig Institute's net income or capital or any other asset owned or managed by the Ludwig Institute. The Ludwig Institute's statutes prohibit the payment of any dividends or distribution of income or capital to the shareholders.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Governing body and management, Line 7b The shareholders have the power to grant discharge to the members of the board of directors and the executive officers at the shareholders' annual meeting for their conduct of business. The annual financial statements are submitted to the shareholders by the board of directors for shareholder approval. The shareholders have the right to make resolutions in respect of mergers, dissolutions or liquidation of the company and of any change of the company's registered office.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section B - Policies, Line 11B The Ludwig Institute's form 990 is reviewed at several levels. The Ludwig Institute's Zurich office senior staff, the vice president, finance, located in New York and external tax counsel review the draft form 990. Following these reviews, the chairperson of the audit committee and the president of the Ludwig Institute review the draft return prior to presenting it to the audit committee for further review. The final draft of form 990 is then presented to the Ludwig Institute's board of directors prior to its submission to the Internal Revenue Service.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section B - Policies, Line 12c The Ludwig Institute has two conflict of interest policies - one for the Board members, Officers and Key Persons, and one for senior staff. Annually all members of the Board of Directors, Officers, Key Persons and senior staff are required to disclose any conflicts of interest. Board members, officers and key persons complete a conflict of interest questionnaire. Senior staff members complete a confidential disclosure form. The completed questionnaires of the members of the Board of Directors, Officers and Key Persons are reviewed by the institute president. Those containing any disclosures or potential conflicts of interest are referred to the chairperson of the audit committee and, if appropriate, to the audit committee. At the same time it is confirmed to the audit committee chairperson that the other individuals had not reported any disclosures or potential conflicts of interest. Following this annual disclosure, if a conflict of interest is subsequently deemed to arise, it is the duty of the individual with the conflict to disclose it. For all cases where a conflict of interest exists, the matter is recorded in the minutes of the meeting of the audit committee or the board. Where the conflict concerns any board or committee member the individual(s) is (are) not permitted to participate in any vote or deliberation on the matter nor be counted in determining the existence of a quorum for the purposes of any action of the board or committee considering the matter. The annual disclosures by senior staff are reviewed by the institute president and escalated as necessary. In addition, during the year, prior to involvement in activities that could be a potential or perceived conflict or interest, individuals are required to provide a written description of such activities to a committee of disinterested officers. Activities determined to be a conflict of interest that are not manageable may not be undertaken by the individual. For activities determined to be a conflict of interest that are manageable, details will be submitted to the audit committee of the Institute board of directors for approval.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section B - Policies, Line 15 The compensation of the members of the board of directors, the executive officers and former directors and officers who are retained as employees or consultants of the Ludwig Institute is subject to review by the Ludwig Institute's compensation committee, which consists of independent members of the board. The compensation reviewed includes the compensation of the chief executive officer, Chi Van Dang. Independent compensation consultants provide comparability surveys to the committee. Organizations selected for peer analysis in the comparability surveys are intended to capture competitor organizations of similar size, revenue /operating budget and industry relevance to the Ludwig Institute. The studies last took place in Fall 2024 and are conducted approximately every three years. Minutes of the review and decisions made by the compensation committee are kept and, once approved by the committee at a subsequent meeting, are signed by the chairperson and the secretary to the board. The compensation committee's decisions are reported to the board of directors and recorded in the minutes of the board meetings, which are kept for all board meetings. Once approved by the board at a subsequent meeting, the minutes of meetings are signed by the chairperson and the secretary to the board.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI - Governance, management and disclosure</FormAndLineReferenceDesc>
        <ExplanationTxt>Section C - Disclosure, Line 19 The annual research highlights, the annual financial reports and the governing documents are available on the website www.ludwigcancerresearch.org under Disclosures and on request at the administrative offices in New York and Zurich, Switzerland.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VII - Compensation of officers, directors, key employees</FormAndLineReferenceDesc>
        <ExplanationTxt>Section A - Officers, directors, trustees, key employees and highest compensated employees, Line 1a As part of the annual preparation of the form 990, all board of directors and executive officers, as well as key employees and highest compensated employees, provide an estimate of hours worked for the Ludwig Institute and the related organizations (see part VII for hours devoted to related organizations). The related organizations report the respective compensation figures to the Ludwig Institute and provide copies of the submitted W-2 returns / 1099 returns.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part XI - Reconciliation of net assets, Line 9</FormAndLineReferenceDesc>
        <ExplanationTxt>Other changes in net assets Net loss on foreign exchange due to operations $ (749,943) Net foreign exchange gain on capital and reserve $ 451,246 ----------- NET LOSS $ (298,697)</ExplanationTxt>
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    </IRS990ScheduleO>
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        <PrimaryActivitiesTxt>See Part VII</PrimaryActivitiesTxt>
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      <LoansOrGuaranteesToOtherOrgInd>false</LoansOrGuaranteesToOtherOrgInd>
      <LoansOrGuaranteesFromOthOrgInd>false</LoansOrGuaranteesFromOthOrgInd>
      <AssetSaleToOtherOrgInd>false</AssetSaleToOtherOrgInd>
      <AssetPurchaseFromOtherOrgInd>false</AssetPurchaseFromOtherOrgInd>
      <AssetExchangeInd>false</AssetExchangeInd>
      <RentalOfFacilitiesToOthOrgInd>false</RentalOfFacilitiesToOthOrgInd>
      <RentalOfFcltsFromOthOrgInd>false</RentalOfFcltsFromOthOrgInd>
      <PerformOfServicesForOthOrgInd>false</PerformOfServicesForOthOrgInd>
      <PerformOfServicesByOtherOrgInd>true</PerformOfServicesByOtherOrgInd>
      <SharingOfFacilitiesInd>true</SharingOfFacilitiesInd>
      <PaidEmployeesSharingInd>false</PaidEmployeesSharingInd>
      <ReimbursementPaidToOtherOrgInd>true</ReimbursementPaidToOtherOrgInd>
      <ReimbursementPaidByOtherOrgInd>true</ReimbursementPaidByOtherOrgInd>
      <TransferToOtherOrgInd>false</TransferToOtherOrgInd>
      <TransferFromOtherOrgInd>false</TransferFromOtherOrgInd>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>LICR Fund Inc</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>c</TransactionTypeTxt>
        <InvolvedAmt>61000000</InvolvedAmt>
        <MethodOfAmountDeterminationTxt>CASH</MethodOfAmountDeterminationTxt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>The Ludwig Group Inc</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>m</TransactionTypeTxt>
        <InvolvedAmt>1963118</InvolvedAmt>
        <MethodOfAmountDeterminationTxt>INVOICE AMOUNTS</MethodOfAmountDeterminationTxt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>The Ludwig Group Inc</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>n</TransactionTypeTxt>
        <InvolvedAmt>637702</InvolvedAmt>
        <MethodOfAmountDeterminationTxt>INVOICE AMOUNTS</MethodOfAmountDeterminationTxt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>The Ludwig Group Inc</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>p</TransactionTypeTxt>
        <InvolvedAmt>823391</InvolvedAmt>
        <MethodOfAmountDeterminationTxt>INVOICE AMOUNTS</MethodOfAmountDeterminationTxt>
      </TransactionsRelatedOrgGrp>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part II, Column 2B - Description of main activity related tax exempt org</FormAndLineReferenceDesc>
        <ExplanationTxt>Tax exempt organizations LICR Fund, Inc. is a Delaware not-for-profit corporation and a supporting organization of the Ludwig Institute, which provides financial support for the Ludwig Institute's conduct of medical research activities. LICR Charitable Trust is a Bermudian trust whose mission is to maintain oversight and control of the management of the Ludwig Institute, including election of the Institute's board of directors.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleR>
  </ReturnData>
</Return>