2025-10-28T10:30:47-05:00 2024-12-31 991856619 GRANT THORNTON ADVISORS LLC 757 THIRD AVENUE 9TH FLOOR NEW YORK NY 100172013 990 2024-01-01 463673346 SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE INC CO WEILL CORNEL SAND 2123278704 1300 YORK AVENUE NEW YORK NY 10065 PETER T MEINKE PHD DIRECTOR 2123278704 2025-10-28 1 1 DANIEL ROMANO P00504182 2125990100 2024 2025-03-06 01:10:19Z PETER T MEINKE PHD 1300 YORK AVENUE NEW YORK NY 10065 16577142 0 X WWW.TRITDI.ORG X 2013 DE TO FURTHER AND IMPROVE HEALTH AND THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASE. 9 0 32 0 0 0 0 330000 18571887 16160405 131317 86737 0 0 18703204 16577142 0 0 0 0 7498439 7847293 0 0 0 11204765 8729849 18703204 16577142 0 0 7953486 7307418 7953486 7307418 0 0 X TO FURTHER AND IMPROVE HEALTH AND THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASE THROUGH RESEARCH, GENERATE INNOVATIVE PROOF-OF-CONCEPT STUDIES, AND ADVANCE THE SCIENTIFIC ACTIVITIES OF THE CONTROLLING INSTITUTIONS. (CONTINUED ON SCHEDULE O)THE SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC. WAS ORGANIZED AND IS OPERATED AS AN INDEPENDENT, NON-PROFIT CORPORATION, CONTROLLED BY LEADING NOT-FOR-PROFIT ACADEMIC, MEDICAL AND RESEARCH INSTITUTIONS, TO FURTHER AND IMPROVE HEALTH AND THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASE THROUGH TRANSLATIONAL RESEARCH, GENERATE INNOVATIVE PROOF-OF-CONCEPT STUDIES, AND ADVANCE THE SCIENTIFIC ACTIVITIES OF THE CONTROLLING INSTITUTIONS (MEMORIAL SLOAN KETTERING CANCER CENTER, THE ROCKEFELLER UNIVERSITY, AND WEILL CORNELL MEDICAL COLLEGE) FACULTY, FELLOWS AND STUDENTS IN ASPECTS OF TRANSLATIONAL RESEARCH, CHEMISTRY, PHARMACOLOGY, AND DRUG DISCOVERY. 0 0 12080116 0 12846683 THE SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, A PARTNERSHIP AMONG THREE WORLD-RENOWNED SCIENTIFIC AND MEDICAL INSTITUTIONS, WORKS TO MORE EFFECTIVELY DEVELOP THERAPEUTICS THAT ARISE FROM DISCOVERIES MADE IN BASIC SCIENCE LABS. WITH A FOCUS ON EARLY-STAGE DRUG DISCOVERY, THE INSTITUTE PROVIDES EXPERTISE IN MEDICINAL CHEMISTRY AND COMPOUND SCREENING, AND CONDUCTS PROOF OF CONCEPT STUDIES NEEDED TO DEMONSTRATE THAT DRUG CANDIDATES CAN SUCCESSFULLY ALTER THE COURSE OF A DISEASE. SPECIFIC RESEARCH PROJECTS FOCUS ON ALZHEIMERS DISEASE, SICKLE CELL, OSTEOPOROSIS, LYSOSOMAL, LIPID DEPOSITS, PARKINSON'S AND BASAL CELL CARCINOMA. 3313722 0 3313722 THE INSTITUTE FACILITATES MORE EFFICIENT SHARING OF CORE FACILITIES BETWEEN THE THREE PARTNER INSTITUTIONS AND FORMS INDUSTRY PARTNERSHIPS WITH PHARMACEUTICAL AND BIOTECH COMPANIES TO FURTHER ADVANCE DRUG RESEARCH. IT SEEKS TO CREATE INTELLECTUAL PROPERTY THAT CAN BE FURTHER DEVELOPED BY AN OPEN FIELD OF INDUSTRY COLLABORATORS. THE MAJORITY OF SUCH SERVICES RELATE TO MEDICINAL CHEMISTRY SUPPORT. 15393838 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 32 0 0 0 0 0 0 0 0 0 0 0 0 0 X 9 0 0 1 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 NY X SANDRA LORBER 6469626161 1230 YORK AVENUE NEW YORK NY 10065 X SELWYN VICKERS MD BOARD MEMBER 0.50 50.00 X 0 6637012 342150 RICHARD P LIFTON MD PHD BOARD MEMBER 0.50 50.00 X 0 1308593 285349 ROBERT HARRINGTON MD BOARD MEMBER 0.50 55.00 X 0 2666653 43901 BARRY COLLER MD BOARD MEMBER 0.50 50.00 X 0 716817 123955 BARBARA HEMPSTEAD MD BOARD MEMBER 0.50 55.00 X 0 810638 50274 DAVID SCHEINBERG MD PHD BOARD MEMBER 0.50 50.00 X 0 685687 71956 CARL NATHAN MD BOARD MEMBER 0.50 55.00 X 0 625253 68608 NATHANIEL HEINTZ PHD BOARD MEMBER 0.50 50.00 X 0 545389 138395 DEREK TAN PHD BOARD MEMBER 0.50 50.00 X 0 490815 85209 PETER T MEINKE PHD SANDERS DIRECTOR 40.00 0.00 X 627542 0 68608 MICHAEL P VITALE TREASURER 0.50 40.00 X 0 449465 144581 MANUEL BACA VICE PRESIDENT, BIOLOGICS 40.00 0.00 X 403018 0 71836 NIGEL LIVERTON PHD VICE PRESIDENT, CHEMISTRY 40.00 0.00 X 290336 0 61066 PAUL BALDERES SR. DIRECTOR 40.00 0.00 X 280506 0 61100 PATRICIA AHA VICE PRESIDENT, OPRATIONS 40.00 0.00 X 300813 0 60121 SANDRA LORBER VICE PRESIDENT, FINANCE 40.00 0.00 X 255246 0 47104 2157461 14936322 1724213 27 0 1 0 WUXI UNIT 10 11/F BLOCK B NEW TRADE PLZ SHA TIN HK PROF SVCS-RESEARCH 2620525 ABLEXIS LLC 533 AIRPORT BLVD SUITE 400 BURLINGAME CA 94010 PROF SVCS-RESEARCH 1000000 SINGLE CELL TECHNOLOGY 6276 SAN IGNACIO AVE SUITE E SAN JOSE CA 95119 PROF SVCS-RESEARCH 301099 WUXI BIOLOGICS 8TH FL OCEAN CTR 5 CANTON RD TST KOWLOON CITY HK PROF SVCS-RESEARCH 199207 VIVA BIOTECH (SHANGHAI) LTD 735 ZIPING RD PUDONG NEW AREA SHANGHAI CH 201318 PROF SVCS-RESEARCH 172386 6 330000 330000 AFFILIATION AGREEMENTS 541700 12846683 12846683 COLLABORATION AGREEMTS 541700 3313722 3313722 16160405 86737 86737 16577142 16160405 0 86737 X 614919 182838 432081 5124094 4730426 393668 1660550 1495411 165139 447730 434050 13680 57131 57131 104887 104887 5089541 5089541 21319 20001 1318 569582 569582 1557930 1542530 15400 34034 34034 373810 373810 84699 84699 SCIENTIFIC MATERIALS 788336 788336 SUMMER PROGRAMS 39000 39000 SPEAKER HONORARIUMS 6000 6000 OTHER PROGRAMS 3000 3000 580 580 16577142 15393838 1183304 0 5570402 4832765 330000 38177 1396089 1421619 4459448 3774591 986995 684857 7953486 7307418 5420818 4341085 2532668 2966333 7953486 7307418 X 0 0 0 0 0 0 7953486 7307418 0 0 X 0 1 X 1 0 X X 3 THE ROCKEFELLER UNIVERSITY 131624158 2 1 0 0 WEILL CORNELL MEDICAL COLLEGE 131623978 2 1 0 0 MEMORIAL SLOAN-KETTERING CANCER CENTER 131924236 3 1 0 0 3 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 4459448 3774591 684857 684857 DUE TO WEILL CORNELL MEDICINE 2966333 2966333 X 16715149 138007 138007 16577142 0 16577142 16715149 138007 138007 16577142 0 16577142 PART X, LINE 2: U.S. GAAP REQUIRES THAT A TAX POSITION BE RECOGNIZED OR DERECOGNIZED BASED ON A "MORE LIKELY THAN NOT" THRESHOLD. THIS APPLIES TO POSITIONS TAKEN OR EXPECTED TO BE TAKEN IN A TAX RETURN. TDI DOES NOT BELIEVE ITS FINANCIAL STATEMENTS INCLUDE ANY UNCERTAIN TAX POSITIONS THAT WOULD HAVE A MATERIALLY ADVERSE EFFECT ON ITS FINANCIAL CONDITION. EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES SCIENTIFIC RESEARCH 2992118 0 0 0 0 0 0 2992118 0 2992118 0 0 0 0 0 0 X X X 0 0 0 0 0 0 0 1 0 SELWYN VICKERS MD BOARD MEMBER 0 3057201 0 3475000 0 104811 0 27600 0 314550 0 6979162 0 0 ROBERT HARRINGTON MD BOARD MEMBER 0 1325789 0 0 0 1340864 0 7209 0 36692 0 2710554 0 0 RICHARD P LIFTON MD PHD BOARD MEMBER 0 1137539 0 0 0 171054 0 59356 0 225993 0 1593942 0 0 BARBARA HEMPSTEAD MD BOARD MEMBER 0 341522 0 0 0 469116 0 33570 0 16704 0 860912 0 0 BARRY COLLER MD BOARD MEMBER 0 643884 0 0 0 72933 0 59245 0 64710 0 840772 0 0 DAVID SCHEINBERG MD PHD BOARD MEMBER 0 679944 0 5743 0 0 0 27600 0 44356 0 757643 0 0 PETER T MEINKE PHD SANDERS DIRECTOR 501977 0 125565 0 0 0 33570 0 35038 0 696150 0 0 0 CARL NATHAN MD BOARD MEMBER 0 500206 0 0 0 125047 0 33570 0 35038 0 693861 0 0 NATHANIEL HEINTZ PHD BOARD MEMBER 0 497808 0 0 0 47581 0 59200 0 79195 0 683784 0 0 MICHAEL P VITALE TREASURER 0 331181 0 0 0 118284 0 58906 0 85675 0 594046 0 0 DEREK TAN PHD BOARD MEMBER 0 490815 0 0 0 0 0 27600 0 57609 0 576024 0 0 MANUEL BACA VICE PRESIDENT, BIOLOGICS 324268 0 78750 0 0 0 33570 0 38266 0 474854 0 0 0 PATRICIA AHA VICE PRESIDENT, OPRATIONS 219368 0 81445 0 0 0 33570 0 26551 0 360934 0 0 0 NIGEL LIVERTON PHD VICE PRESIDENT, CHEMISTRY 243105 0 47231 0 0 0 33570 0 27496 0 351402 0 0 0 PAUL BALDERES SR. DIRECTOR 244831 0 35675 0 0 0 33570 0 27530 0 341606 0 0 0 SANDRA LORBER VICE PRESIDENT, FINANCE 215620 0 39626 0 0 0 33570 0 13534 0 302350 0 0 0 PART I, LINE 7 A DISCRETIONARY BONUS PROVIDED TO AN INDIVIDUAL LISTED ON FORM 990, PART VII, SECTION A, LINE 1A WAS BASED ON THE ACHIEVEMENT OF SIGNIFICANT QUANTITATIVE, QUALITATIVE, AND/OR PROGRAMMATIC GOALS AND WAS APPROVED BY THE BOARD OF DIRECTORS OF THE ORGANIZATION. FORM 990, PART VI, SECTION A, LINE 3 AFFILIATED ORGANIZATIONS PERFORM VARIOUS ADMINISTRATIVE FUNCTIONS FOR TDI INCLUDING ACCOUNTING, PURCHASING AND TREASURY. FORM 990, PART VI, SECTION A, LINE 3 THE MEMBERS OF INSTITUTE ARE MEMORIAL SLOAN KETTERING CANCER CENTER, THE ROCKEFELLER UNIVERSITY, AND WEILL CORNELL MEDICAL COLLEGE. FORM 990, PART VI, SECTION B, LINE 11B ALL BOARD MEMBERS RECEIVE A COPY OF FORM 990 TWO WEEKS IN ADVANCE OF ITS FILING. BOARD MEMBERS ARE ENCOURAGED TO CONTACT MANAGEMENT IF THEY HAVE ANY QUESTIONS. FORM 990, PART VI, SECTION B, LINE 12C TDI HAS ADOPTED A FORMAL CONFLICT OF INTEREST POLICY IN ORDER TO PROTECT THE INTEREST OF TDI WHEN IT IS CONTEMPLATING ENTERING INTO A TRANSACTION OR ARRANGEMENT WHERE THE FINANCIAL INTERESTS OF AN OFFICER OR DIRECTOR OF THE INSTITUTE MAY DIVERGE FROM THE INTERESTS OF THE INSTITUTE. ON AN ANNUAL BASIS, EACH DIRECTOR AND OFFICER SHALL SIGN A STATEMENT WHICH AFFIRMS SUCH PERSON: A. HAS RECEIVED A COPY OF THE CONFLICT OF INTEREST POLICY; B. HAS READ AND UNDERSTANDS THE POLICY; C. HAS AGREED TO COMPLY WITH THE POLICY, AND D. UNDERSTANDS THE INSTITUTE IS CHARITABLE AND IN ORDER TO MAINTAIN ITS FEDERAL TAX EXEMPTION IT MUST ENGAGE PRIMARILY IN ACTIVITIES WHICH ACCOMPLISH ONE OF MORE OF ITS TAX-EXEMPT PURPOSES. THE TDI BY-LAWS STATE THAT THE BOARD CONSIST OF A MINIMUM TOTAL OF TWO DIRECTORS FROM EACH FOUNDING INSTITUTION, FOR A TOTAL OF NINE DIRECTORS; NONE OF WHOM HAD A BUSINESS RELATIONSHIP OUTSIDE OF THEIR OWN INSTITUTION. FORM 990, PART VI, SECTION B, LINE 15 COMPENSATION FOR THE DIRECTOR IS ESTABLISHED AND APPROVED BY THE BOARD. SUCH COMPENSATION IS ESTABLISHED THROUGH REVIEW OF COMPARABILITY DATA AND CONTEMPORANEOUS SUBSTANTIATION OF THE DELIBERATION AND DECISION. SPECIFIC REVIEWS OCCUR ON AN ANNUAL BASIS. A STAFF SECONDMENT AGREEMENT WAS ENTERED INTO ON JULY 6, 2014 BETWEEN CORNELL UNIVERSITY ON BEHALF OF ITS WEILL CORNELL MEDICAL COLLEGE (WCMC) AND TDI. THE AGREEMENT STATES THAT WCMC WILL PROVIDE SECONDED EMPLOYEES TO TDI. THE AGREEMENT FURTHER STATES THAT WCMC WILL PROVIDE ALL SALARIES AND BENEFITS TO ALL SECONDED EMPLOYEE AND BE RESPONSIBLE FOR ALL TAX REPORTING AND WITHHOLDINGS. IN TURN, TDI AGREES TO REIMBURSE WCMC FOR ALL RELATED EMPLOYMENT COSTS. THE TERM OF THE AGREEMENT IS ONE YEAR EXPIRING ON JUNE 30, 2015, AND SHALL BE RENEWED THEREAFTER FOR SUCCESSIVE ONE YEAR TERMS UNLESS IT IS TERMINATED BY EITHER PARTY. AN UPDATED AGREEMENT WAS SIGNED AND EXPIRED ON DECEMBER 31, 2024. TDI HAD 32 SECONDED EMPLOYEES IN 2024. FORM 990, PART VI, SECTION C, LINE 19 CONFLICT OF INTEREST POLICIES ARE MADE AVAILABLE THROUGH THE WEILL CORNELL MEDICAL COLLEGE'S WEB SITE. FORM 990, PART VII, SECTION A: WAGES PAID BY RELATED ORGANIZATION TO THE TDI BOARD OF DIRECTORS ARE NOT TIED INTO THEIR SERVICES AT TDI. THE BOARD MEMBERS ACT IN A VOLUNTARY CAPACITY AT TDI. FORM 990, PART IX, LINE 11G CHEMISTRY SUPPORT: PROGRAM SERVICE EXPENSES 5,089,541. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 5,089,541. THE ROCKEFELLER UNIVERSITY 1230 YORK AVENUE NEW YORK NY 100656307 131624158 EDUCATION NY 501(C)(3) LINE 2 N/A 0 MEMORIAL SLOAN-KETTERING CANCER CENTER 1275 YORK AVENUE NEW YORK NY 100656007 131924236 HOSPITAL NY 501(C)(3) LINE 3 N/A 0 WEILL CORNELL MEDICAL COLLEGE 1300 YORK AVENUE NEW YORK NY 10021 131623978 EDUCATION NY 501(C)(3) LINE 2 CORNELL UNIVERSITY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0