2024-12-20T17:55:44-07:00 2023-12-31 990 2023-01-01 264489946 SAGE BIONETWORKS SAGE 2069288250 2901 Third Ave Ste 330 Seattle WA 98121 Luca Foschini President 2069288250 2024-12-20 1 2023 2024-10-15 13:58:12Z Luca Foschini 2901 Third Ave Ste 330 Seattle WA 98121 26329869 0 X www.sagebionetworks.org X 2009 WA Sage Bionetworks is on a mission to drive a new age of discovery through truly open science and radical collaboration. We aim to create a world where silos within and across science and technology no longer exist, forging a path to optimal human health. 8 7 146 7 0 0 19139955 20131088 4767966 6198781 120 0 3000 0 23911041 26329869 1572423 2177616 0 0 16796690 19247056 0 30434 130842 5852039 4952847 24221152 26407953 -310111 -78084 11242073 10800289 7577144 7213444 3664929 3586845 Sage Bionetworks is a nonprofit research organization founded in 2009 to accelerate the translation of data-intensive science into medicine. Drawing on our roots in open science, we develop and apply community practices that address barriers that limit the implementation and interpretation of computational biomedical research. We are modernizing how biomedical data and insights are collected, managed, and used, and we partner with scientists in academia, industry and the nonprofit sectors to ensure that data-intensive science programs lead to actionable results. 0 0 18967765 1771385 20316141 Research Communities and Challenges: Sage Bionetworks conducts research independently as well as with collaborators worldwide across a variety of disease areas. We work to redefine how complex biological data is gathered, shared and used through open systems, incentives, and norms. Our work includes the building of platforms and services and undertaking research developing predictors relating to health. Research: As biological research has become more data intensive, the breadth of data and expertise required to address research problems has expanded. It requires the integrated efforts of a distributed set of researchers (such as bench/data scientists, data engineers, project managers, administrators, governance experts, and clinical researchers) with shared interests and complementary resources. Effective collaboration depends on a collective ability to work together in trusted ways that lead to translatable biomedical insights. We call this scientific coordination. Sage's scientific coordination stack includes: 1) hypothesis and data generation, 2) data curation, 3) analysis, 4) interpretation, and 5) dissemination. We focus on building a federated network of individuals who bring diverse expertise and approaches to develop robust solutions. Research projects include AMP AD and supplements, TREAT AD, Model AD, RISK Variants, Helmsley VEIOBD, Boston Children's Hospital VEIOBD, MC2, CHOP INCLUDE, CTF Synodos, JHU NTAP, GFF NF, Gray Foundation, Gates COVID Cohort, Exposome, HTAN, CRI iAtlas 4, AACR Genie, Bridge 2 AI, CD2H, Rochester Udall, UMass PECDCC, AoU Governance, Mayo Subtyping, and RWJF Community Consent in Biorepositories in addition to other projects. Challenges: With algorithms playing an increasing role in biomedical analysis and patient care, there's a need for a more rigorous framework for evaluating and improving the capabilities of these algorithms. Sage Bionetworks has pioneered the development of concepts and infrastructure to objectively evaluate algorithms across a broad spectrum of biomedical domains, including bioinformatics, biomedical informatics, and clinical trials. As a trusted partner in hosting challenges and benchmarking initiatives, Sage serves as a broker between data generators and data modelers. We combine technology with biomedical and data science expertise to facilitate the objective assessment of algorithms on critical data sets, including proprietary data and algorithms that cannot be broadly shared. Sage works with the DREAM community to host open challenges. DREAM is recognized as a leader in biomedical competitions, successfully motivating research teams to address fundamental questions about systems biology and translational medicine and to advance computational methods. DREAM challenges invite participants to propose solutions - fostering collaboration and building communities in the process. Sage Bionetworks provides institutional support, along with the infrastructure to host challenges via our Synapse platform. Active Challenges hosted on the Synapse platform in 2023 included: RADx Long Covid, BRATS Data Centric Challenge, PEGS Gene Challenge, FINRISK Dream Challenge, UW/NSF Dynamic Challenge, Open Band Challenge, RARE-X, NIH ITCR, and NLP DREAM. 5472600 406231 6005445 Digital Health: Smartphones and other wearable sensors have put touchscreens and high-fidelity sensors into the pockets of billions of people. These technologies provide an opportunity to paint a rich understanding of health and disease in the everyday world outside of the clinic. They also provide communication tools that allow participants a more active voice in research programs. With our Digital Health program, we work to advance health research through practices that support the design, development and implementation of studies that use technology to monitor health outside of the clinical setting, and the analysis and sharing of the resulting study data. We help to derive and test digital biomarkers. We evaluate analytical methodologies to benchmark best practices in study design and data analysis. Sage's Digital Health program is built around Bridge, a technology platform for conducting biomedical research. Bridge is composed of HIPAA-compliant web services and multi-language SDKs that facilitate: registration and informed consent to participate in research; web-based tools to design and schedule study surveys and sensor-based tasks; acquisition and secure transfer of multiple data types (surveys, sensors, audio, video, or custom data types); a study management portal with daily dashboard updates; and de-identification and storage of study data in our collaborative data science environment, Synapse. Digital Health studies active in 2023 included: Scripps AoU, NWU Toolbox, DIAN, MGH At Home, Wellcome Trust Databank, M2C2, RECOVER Mobile Health Platform/Mobile Health Repositories, and the 1KD Program funded by Wellcome LEAP Inc. 0 0 0 24440365 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1 0 1 0 0 1 0 1 0 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 13 0 1 146 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 X 8 7 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 0 0 WA X X X Kim Baggett 2069288243 2901 Third Ave Ste 330 Seattle WA 98121 Luca Foschini President & CEO 50 0 X X 419183 0 33123 Kim Baggett COO 50 0 X 286765 0 47354 Brian O'Connor Chief Data Officer 50 0 X 263068 0 33189 Mike Kellen Chief Technology Officer 50 0 X 246427 0 23863 Bruce Hoff Director, Synapse Team 50 0 X 192648 0 41445 Ljubomir Bradic Director, Design 50 0 X 193431 0 38130 Julie Bletz Director, SCCE 50 0 X 185014 0 42245 Christine Fabre Suver Chief Privacy & Compliance Officer 50 0 X 186755 0 37263 Jay Hodgson Director, Web Engineering Team 50 0 X 184652 0 34534 Erin Mounts Director, Bridge Platforms 50 0 X 191970 0 24869 Anna Greewood Director, ADTR 50 0 X 179965 0 35667 Larsson Omberg Vice President, Systems Biology 50 0 X 111269 0 20698 Stephen Friend Chairman of the Board 1 0 X 0 0 0 Eric Schadt Director 1 0 X 0 0 0 Tony Ford-Hutchinson Director 1 0 X 0 0 0 Gustavo Stolovitsky Director 1 0 X 0 0 0 Cecilia Arradaza Director 1 0 X 0 0 0 Tetsu Maruyama Director 1 0 X 0 0 0 Carole Goble Director 1 0 X 0 0 0 2641147 0 412380 71 0 1 0 PARIS PHOENIX GROUP LLC 22932 NE 150TH ST WOODENVILLE WA 98077 HR Management Consulting 123275 1 0 0 0 0 18863752 1267336 0 20131088 6198781 6198781 0 0 6198781 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26329869 6198781 0 0 2077793 2077793 0 0 99823 99823 0 0 1693431 1257271 403984 32176 0 0 0 0 13316327 12387301 890441 38585 943040 861128 77666 4246 2143194 2004707 131320 7167 1151064 1030167 114621 6276 302317 274819 26072 1426 37382 33982 3224 176 236766 212463 23042 1261 0 0 0 0 30434 30434 0 0 0 0 2237260 2233246 3806 208 0 0 0 0 212443 194046 17443 954 113801 103465 9800 536 0 0 0 0 1066199 969226 91947 5026 353592 338269 14529 794 0 0 0 0 77337 75475 1765 97 0 0 0 0 0 16581 15073 1430 78 79794 72537 6881 376 Other Expenses 219375 199574 18775 1026 26407953 24440365 1836746 130842 1418950 1982938 0 0 0 0 4269310 4114951 0 0 0 0 0 0 0 0 249287 298535 4520444 116579 5304526 4403865 0 0 0 0 0 0 0 0 0 0 11242073 10800289 1149973 1068644 0 0 897810 1488265 0 0 0 0 0 0 0 0 0 0 5529361 4656535 7577144 7213444 X 3645836 3584900 19093 1945 3664929 3586845 11242073 10800289 -78084 0 0 0 0 X 1 X 1 X 1 1 1 X 13586784 15521559 17940132 19068754 17594452 83711681 0 0 0 0 0 0 0 0 0 0 0 0 13586784 15521559 17940132 19068754 17594452 83711681 83711681 351 414 79 120 0 964 0 0 0 3000 0 3000 3116572 3890449 8456518 4767966 6196819 26428324 110143969 0 0.76002 0.77640 X Schedule A, Part II, Line 10 Fee for service revenue from research collaborations. RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 0 0 0 0 0 0 0 0 0 0 152111 0 116579 35532 4368333 0 0 4368333 4403865 0 Office Space Lease Obligation 4656535 4656535 27471590 0 1141721 0 0 1141721 26329869 0 0 0 26329869 27549674 1141721 0 0 0 1141721 26407953 0 0 0 26407953 Europe (including Iceland and Greenland) Wellcome is engaging Sage Bionetworks as a learning partner to prototype and test best ways to build a Global Metal Health Databank that holds rich longitudinal data at scale from different global locations on approaches, treatments and interventions potentially relevant to anxiety or depression in 14-24 year olds in order to help answer the question: "what works for whom and why in relation to prevention, treatment, stopping relapse or managing ongoing difficulties for anxiety or depression including at least some 14-24 year olds". 60862 Wire 0 South Asia Wellcome is engaging Sage Bionetworks as a learning partner to prototype and test best ways to build a Global Metal Health Databank that holds rich longitudinal data at scale from different global locations on approaches, treatments and interventions potentially relevant to anxiety or depression in 14-24 year olds in order to help answer the question: "what works for whom and why in relation to prevention, treatment, stopping relapse or managing ongoing difficulties for anxiety or depression including at least some 14-24 year olds". 16184 Wire Sub-Saharan Africa Wellcome is engaging Sage Bionetworks as a learning partner to prototype and test best ways to build a Global Metal Health Databank that holds rich longitudinal data at scale from different global locations on approaches, treatments and interventions potentially relevant to anxiety or depression in 14-24 year olds in order to help answer the question: "what works for whom and why in relation to prevention, treatment, stopping relapse or managing ongoing difficulties for anxiety or depression including at least some 14-24 year olds". 22776 Wire 0 1 1 0 0 0 0 0 0 1 Nicholson Advancement LLC 487 Whitman ST Apt A Goleta CA 93117 Assisted in building a strategy for soliciting contributions and initial setup of a donor CRM system. 0 0 34437 -34437 0 34437 -34437 WA 1 Duke University 2200 W Main St Ste 710 Durham NC 27705 560532129 203859 0 Phase 1 and 2: RECOVER Mobile Health Platform/Mobile Health Repositories Working Group: Develop process for MHP to collect PASC related mobile health data from participants and share this data with MHDR to clean curate, conduct QA/QC, store and provide access to researchers. Customization of the mobile health platform, implementation of mobile data collection among the various studies, as well as, the storing, curation, linkage, and analyses of the mobile health data. Harvard Office of Sponsored Programs 1635 Tremont St Boston MA 02120 042103580 164066 0 Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research. Institute for Systems Biology 401 Terry Ave N Seattle WA 98109 912003593 379595 0 CRI Immune Atlas4: Platform for immune-oncology research and data sharing. Exceptional Longevity Data Management and Coordinating Center, design and perform cross-project analysis focused on harnessing systems biology-based techniques, such as multi-omic data integration, network analysis, machine learning, and statistical modeling, to investigate both aging and disease, as well as the interplay between them. Memorial Sloan-Kettering Cancer Center 1275 York Ave New York NY 10065 131924236 204479 0 Perform all work related to the proposed BRCA Pre-Cancer Atlas instance of the cBioPortal for Cancer Genomics. Build, maintain and run automated pipelines that transfer data from Synapse into BRCA Pre-Cancer Atlas Data Portal. Maintain all user logins and develop new Data Portal and cBioPortal features as they become relevant for the project. Provide user support, documentation, and outreach for the entire BRCA Pre Cancer Atlas. Pennsylvania State University 110 Technology Center Building University Park PA 16802 246000376 194842 0 Phase 1 and 2: RECOVER Mobile Health Platform/Mobile Health Repositories Working Group: Develop process for MHP to collect PASC related mobile health data from participants and share this data with MHDR to clean curate, conduct QA/QC, store and provide access to researchers. Customization of the mobile health platform, implementation of mobile data collection among the various studies, as well as, the storing, curation, linkage, and analyses of the mobile health data. Seven Bridges Genomics Inc 529 Main St Ste 6610 Boston MA 02129 453415885 199853 0 Exceptional Longevity Data Management and Coordinating Center, develop integration between Sage's data sharing portal, Synapse, and CABATICA. University of California Los Angeles 405 Hilgard Ave Los Angeles CA 90095 943067788 208563 0 ITCR, lead evaluation and testing of new Synapse features and their incorporation into multiple challenges, including a lead study of prostate cancer Active Surveillance. Provide strategic advice, feature-testing and development, usage-scenarios and intensive testing. Translational Genomics Research Institute 445 N Fifth St Phoenix AZ 85004 753065445 154554 0 Exceptional Longevity Data Management and Coordinating Center, develop analytical methods for accommodating and exploring heterogeneity in large aggregated databases. They will also apply these methods with the other investigators as well as researchers associated with the consortia that generated the aggregated data. University of California San Francisco 490 Illinois St 6th Floor San Francisco CA 94143 946036493 5313 0 Phase 1 and 2: RECOVER Mobile Health Platform/Mobile Health Repositories Working Group: Develop process for MHP to collect PASC related mobile health data from participants and share this data with MHDR to clean curate, conduct QA/QC, store and provide access to researchers. Customization of the mobile health platform, implementation of mobile data collection among the various studies, as well as, the storing, curation, linkage, and analyses of the mobile health data. University of Colorado Denver 2199 S University Blvd Denver CO 80208 840644739 23919 0 Provide support for governance issues and regulatory coordination with NIH, providing technical management support for project teams, training and coordination for sites to participate in analytical activities, and support for public relations and dissemination of research outcomes for the COVID 19 Cohort Collaborative for Disease Modeling project. University of North Carolina at Chapel Hill 910 Raleigh Rd 3916 Chapel Hill NC 27514 566001393 163934 0 CRI Immune Atlas4: Platform for immune-oncology research and data sharing. Defining regression models and validation methods for use in implementing statistical learning models for biomarker development in iAtlas. Add comprehensive tumor antigen prediction from multiple genomic sources to iAtlas datasets. Harmonize and curate data from additional IO clinical trials with genomic data for analysis using the IO response module. University of Winsconsin-Madison 21 N Park St Ste 6301 Madison WI 53715 396006492 71103 0 Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research. Yale University 9 Hillhouse Ave New Haven CT 06511 060646973 102541 0 Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research. 14 1 Schedule I, Part I, Line 2 Sage Bionetworks issued grants, contributions, and prizes. Contributions were given in support of an awarded institution's project and prizes were awarded to research challenge winners. Monitoring the use of grant funds: In some cases, grants received by Sage Bionetworks are passed on to sub-recipients through a sub-award agreement. The Grant Manager is responsible for initiating the sub-award after obtaining budget approval from the PI and Operations Director. In issuing a sub-award, the Grant Manager is responsible for: obtaining verification of the sub-awardee's facilities and administrative rates and Single Audit Reports; reviewing the prime award special terms and conditions to determine whether they are applicable to the sub-award; and determining whether the sub-awardee meets all of the other administrative and regulatory requirements of the prime award. Once the sub-award has been issued, the Grant Manager is responsible for monitoring sub-award activity, including compliance with all reporting requirements. The Grant Manager is also responsible for forwarding the fully executed sub-award documents to the Accounting Manager to ensure proper billing. Payments are made only after the sub-award agreement has been fully executed by both parties. X 0 0 0 0 0 0 0 0 0 Luca Foschini President & CEO 368269 0 50000 0 913 0 0 0 33123 0 452305 0 0 Kim Baggett COO 286765 0 0 0 0 0 0 0 47354 0 334119 0 0 0 Brian O'Connor Chief Data Officer 263068 0 0 0 0 0 0 0 33189 0 296257 0 0 0 Mike Kellen Chief Technology Officer 246300 0 0 0 127 0 0 0 23863 0 270290 0 0 0 Ljubomir Bradic Director, Design 193431 0 0 0 0 0 0 0 38130 0 231561 0 0 0 Bruce Hoff Director, Synapse Team 192648 0 0 0 0 0 0 0 41445 0 234093 0 0 0 Erin Mounts Director, Bridge Platforms 191970 0 0 0 0 0 0 0 24869 0 216839 0 0 0 Christine Fabre Suver Chief Privacy & Compliance Officer 186755 0 0 0 0 0 0 0 37263 0 224018 0 0 0 Julie Bletz Director, SCCE 185014 0 0 0 0 0 0 0 42245 0 227259 0 0 0 Jay Hodgson Director, Web Engineering Team 184652 0 0 0 0 0 0 0 34534 0 219186 0 0 0 Anna Greewood Director, ADTR 179965 0 0 0 0 0 0 0 35667 0 215632 0 0 0 Schedule J, Part I, Line 3 Executive compensation was set by the Board of Directors Compensation Committee. 0 0 1 0 Form 990, Part VI, Section B, Line 11b The 990 is reviewed by the company's Director of Finance, COO and President prior to filing. Form 990, Part VI, Section B, Line 12c Sage Bionetworks has a Financial Conflict of Interest Policy (FCOI) that complies with the National Institutes of Health-specific requirements promoting objectivity in research, 42 CFR Part 50 subpart F. On an annual basis, Sage Bionetworks Officers, Directors, and members of committees of Board of Directors authorized to act on behalf of the board, and employees designated by the President of Sage Bionetworks, including any employees serving as an investigator on a federal/Public Health Services award, must review and update the Sage Bionetworks Annual Conflict of Interest Questionnaire. New employees serving as investigators are required to complete a FCOI form within 30 days of their start date. In addition, all investigators must submit an ad hoc disclosure of an Significant Financial Interest they acquire or discover during the course of the year within 30 days of discovering or acquiring the Significant Financial Interest. Forms are reviewed and any potential conflicts are referred to the President and outside counsel. Form 990, Part VI, Section B, Line 15 Executive compensation is set by the Board of Directors Compensation Committee. Form 990, Part VI, Section C, Line 19 The organization's financials are contained within its 990 returns. These returns are available to the public through organizations such as Guidestar, dedicated to publicizing information about nonprofit organizations. The organization's governing documents and conflict of interest policies are available upon request. The late filing of this return was due to turnover of key team members involved in the preparation process, as well as challenges related to the availability of personnel at the time of the deadline. This is the first time the organization has been late in filing, and we do not expect such an extraordinary situation to occur again in the future.