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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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        <GrantOrContributionPdDurYrGrp>
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            <ZIPCd>06820</ZIPCd>
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          <RecipientFoundationStatusTxt>PC</RecipientFoundationStatusTxt>
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        <GrantOrContributionPdDurYrGrp>
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            <BusinessNameLine1Txt>DARIEN LIBRARY</BusinessNameLine1Txt>
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            <ZIPCd>06820</ZIPCd>
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            <BusinessNameLine1Txt>FOOD BANK OF LOWER FAIRFIELD COUNTY</BusinessNameLine1Txt>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>PC</RecipientFoundationStatusTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>LAND TRUST OF DARIEN INC</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>P O BOX 1074</AddressLine1Txt>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>PC</RecipientFoundationStatusTxt>
          <GrantOrContributionPurposeTxt>GENERAL SUPPORT</GrantOrContributionPurposeTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>MALT HOUSE OF GOOD COUNCIL</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>139 WEST ROCKS ROAD</AddressLine1Txt>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06851</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>MIDDLEBURY COLLEGE</BusinessNameLine1Txt>
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          <RecipientUSAddress>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
          <RecipientFoundationStatusTxt>PC</RecipientFoundationStatusTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>PERSON TO PERSON</BusinessNameLine1Txt>
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          <RecipientUSAddress>
            <AddressLine1Txt>1864 POST ROAD</AddressLine1Txt>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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          <RecipientFoundationStatusTxt>PC</RecipientFoundationStatusTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>PRESIDENT AND FELLOWS OF HARVARD COLLEGE</BusinessNameLine1Txt>
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            <AddressLine1Txt>1033 MASSACHUSTES AVENUE</AddressLine1Txt>
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            <StateAbbreviationCd>MA</StateAbbreviationCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>ST THOMAS MORE PARISH</BusinessNameLine1Txt>
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            <AddressLine1Txt>374 MIDDLESEX ROAD</AddressLine1Txt>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE COMMUNITY FUND OF DARIEN</BusinessNameLine1Txt>
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            <AddressLine1Txt>30 KINGS HIGHWAY SOUTH</AddressLine1Txt>
            <CityNm>DARIEN</CityNm>
            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE DARIEN FOUNDATION</BusinessNameLine1Txt>
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            <AddressLine1Txt>5 BROOK STREET</AddressLine1Txt>
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            <StateAbbreviationCd>CT</StateAbbreviationCd>
            <ZIPCd>06820</ZIPCd>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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          <RecipientBusinessName>
            <BusinessNameLine1Txt>THE ROWAN CENTER INC</BusinessNameLine1Txt>
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          <RecipientBusinessName>
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            <BusinessNameLine1Txt>TRUSTEES OF DEERFIELD ACADEMY</BusinessNameLine1Txt>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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          <RecipientBusinessName>
            <BusinessNameLine1Txt>UATX</BusinessNameLine1Txt>
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            <AddressLine1Txt>522 CONGRESS AVE</AddressLine1Txt>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
            <BusinessNameLine1Txt>WESTMINSTER SCHOOL</BusinessNameLine1Txt>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
          <RecipientBusinessName>
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          <RecipientRelationshipTxt>N/A</RecipientRelationshipTxt>
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        <GrantOrContributionPdDurYrGrp>
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            <BusinessNameLine1Txt>HEADSTRONG FOUNDATION</BusinessNameLine1Txt>
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            <AddressLine1Txt>1330 MACDADE BLVD 2</AddressLine1Txt>
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            <StateAbbreviationCd>PA</StateAbbreviationCd>
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            <BusinessNameLine1Txt>WEE BURN CADDY SCHOLARSHIP FUND</BusinessNameLine1Txt>
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            <BusinessNameLine1Txt>KOLBE CATHEDRAL CATHOLIC HIGH SCHOOL INC</BusinessNameLine1Txt>
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            <BusinessNameLine1Txt>ONE PLYMPTON PRESERVATION FOUNDATION INC</BusinessNameLine1Txt>
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        <EOYFMVAmt>1549700</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>16,000 SHARES, ARGENX SE-ADR</StockNm>
        <EOYBookValueAmt>1746662</EOYBookValueAmt>
        <EOYFMVAmt>6068880</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>15,000 SHARES, INCYTE CORP</StockNm>
        <EOYBookValueAmt>1192911</EOYBookValueAmt>
        <EOYFMVAmt>941850</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>10,000 SHARES, INTEL CORP.</StockNm>
        <EOYBookValueAmt>291390</EOYBookValueAmt>
        <EOYFMVAmt>502500</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>3,000 SHARES IONIS PHARMACEUTICALS INC.</StockNm>
        <EOYBookValueAmt>131213</EOYBookValueAmt>
        <EOYFMVAmt>151770</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>9,693 SHARES, MORPHOSYS AG ADR</StockNm>
        <EOYBookValueAmt>80973</EOYBookValueAmt>
        <EOYFMVAmt>95961</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>5,000 SHARES, NOVO NORDISK A.S. FORMERLY NOVO INDUSTRIE A.S. ADR</StockNm>
        <EOYBookValueAmt>106549</EOYBookValueAmt>
        <EOYFMVAmt>517250</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>25,000 SHARES PROTHENA CORPORATION PLC</StockNm>
        <EOYBookValueAmt>384338</EOYBookValueAmt>
        <EOYFMVAmt>908500</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>3,000 SHARES,REGENERON PHARMACEUTICALS INC., COMMON</StockNm>
        <EOYBookValueAmt>1673670</EOYBookValueAmt>
        <EOYFMVAmt>2634870</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
      <InvestmentsCorporateStockGrp>
        <StockNm>120,000 SHARES, XENCOR, INC., COMMON</StockNm>
        <EOYBookValueAmt>3011620</EOYBookValueAmt>
        <EOYFMVAmt>2547600</EOYFMVAmt>
      </InvestmentsCorporateStockGrp>
    </InvestmentsCorpStockSchedule>
    <InvestmentsOtherSchedule2 documentId="RetDoc2018100001">
      <InvestmentsOtherGrp>
        <CategoryOrItemTxt>107,175 SHARES EVOTEC SE</CategoryOrItemTxt>
        <ListedAtCostOrFMVCd>AT COST</ListedAtCostOrFMVCd>
        <BookValueAmt>1561671</BookValueAmt>
        <EOYFMVAmt>1275163</EOYFMVAmt>
      </InvestmentsOtherGrp>
      <InvestmentsOtherGrp>
        <CategoryOrItemTxt>7,000 SHARES, MORPHOSYS AG SHARES</CategoryOrItemTxt>
        <ListedAtCostOrFMVCd>AT COST</ListedAtCostOrFMVCd>
        <BookValueAmt>456934</BookValueAmt>
        <EOYFMVAmt>256939</EOYFMVAmt>
      </InvestmentsOtherGrp>
      <InvestmentsOtherGrp>
        <CategoryOrItemTxt>1,000 SHARES, VANECK OIL SERVICES ETF</CategoryOrItemTxt>
        <ListedAtCostOrFMVCd>AT COST</ListedAtCostOrFMVCd>
        <BookValueAmt>318713</BookValueAmt>
        <EOYFMVAmt>309520</EOYFMVAmt>
      </InvestmentsOtherGrp>
      <InvestmentsOtherGrp>
        <CategoryOrItemTxt>REFLEXION PHARMACEUTICALS INC</CategoryOrItemTxt>
        <ListedAtCostOrFMVCd>AT COST</ListedAtCostOrFMVCd>
        <BookValueAmt>229326</BookValueAmt>
        <EOYFMVAmt>229326</EOYFMVAmt>
      </InvestmentsOtherGrp>
    </InvestmentsOtherSchedule2>
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      <LegalFeesGrp>
        <CategoryTxt>LEGAL FEES</CategoryTxt>
        <LegalFeesAmt>228</LegalFeesAmt>
        <NetInvestmentIncomeAmt>228</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>0</DisbursementsCharitablePrpsAmt>
      </LegalFeesGrp>
    </LegalFeesSchedule>
    <OtherExpensesSchedule documentId="RetDoc2003200001">
      <OtherExpensesScheduleGrp>
        <Desc>BANK FEES</Desc>
        <RevenueAndExpensesPerBooksAmt>105</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>105</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>OTHER INVESTMENT FEES</Desc>
        <RevenueAndExpensesPerBooksAmt>255</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>255</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>0</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>OFFICE EXPENSE</Desc>
        <RevenueAndExpensesPerBooksAmt>133</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>133</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>HOCKEY PROGRAM IN CONNECTION WITH THE WATERSIDE SCHOOL</Desc>
        <RevenueAndExpensesPerBooksAmt>184136</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>184136</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
      <OtherExpensesScheduleGrp>
        <Desc>HARLEM LACROSSE PROGRAM</Desc>
        <RevenueAndExpensesPerBooksAmt>414050</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>414050</DisbursementsCharitablePrpsAmt>
      </OtherExpensesScheduleGrp>
    </OtherExpensesSchedule>
    <OtherIncomeSchedule2 documentId="RetDoc2001500001">
      <OtherIncomeDetail>
        <Desc>FOREIGN EXCHANGE GAIN</Desc>
        <RevenueAndExpensesPerBooksAmt>12400</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>12400</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>12400</AdjustedNetIncomeAmt>
      </OtherIncomeDetail>
      <OtherIncomeDetail>
        <Desc>LIQUIDATING DIVIDEND</Desc>
        <RevenueAndExpensesPerBooksAmt>24975</RevenueAndExpensesPerBooksAmt>
        <NetInvestmentIncomeAmt>24975</NetInvestmentIncomeAmt>
        <AdjustedNetIncomeAmt>24975</AdjustedNetIncomeAmt>
      </OtherIncomeDetail>
    </OtherIncomeSchedule2>
    <OtherProfessionalFeesSchedule documentId="RetDoc2002300001">
      <OtherProfessionalFeesDetail>
        <CategoryTxt>INVESTMENT FEES AND COMMISSIONS</CategoryTxt>
        <Amt>4380</Amt>
        <NetInvestmentIncomeAmt>4380</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>0</DisbursementsCharitablePrpsAmt>
      </OtherProfessionalFeesDetail>
    </OtherProfessionalFeesSchedule>
    <SubstantialContributorsSch documentId="RetDoc2089200001">
      <SubstantialContributorDetail>
        <PersonNm>RICHARD VAN DEN BROEK</PersonNm>
        <USAddress>
          <AddressLine1Txt>11 FOX HILL LANE</AddressLine1Txt>
          <CityNm>DARIEN</CityNm>
          <StateAbbreviationCd>CT</StateAbbreviationCd>
          <ZIPCd>06820</ZIPCd>
        </USAddress>
      </SubstantialContributorDetail>
      <SubstantialContributorDetail>
        <PersonNm>MERRILL VAN DEN BROEK</PersonNm>
        <USAddress>
          <AddressLine1Txt>11 FOX HILL LANE</AddressLine1Txt>
          <CityNm>DARIEN</CityNm>
          <StateAbbreviationCd>CT</StateAbbreviationCd>
          <ZIPCd>06820</ZIPCd>
        </USAddress>
      </SubstantialContributorDetail>
    </SubstantialContributorsSch>
    <TaxesSchedule documentId="RetDoc2002500001">
      <TaxesDetail>
        <CategoryTxt>FOREIGN TAX WITHHELD ON SECURITY TRANSACTIONS</CategoryTxt>
        <Amt>2776</Amt>
        <NetInvestmentIncomeAmt>2776</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>0</DisbursementsCharitablePrpsAmt>
      </TaxesDetail>
      <TaxesDetail>
        <CategoryTxt>PRIOR YEAR EXCISE TAXES PAID IN CURRENT YEAR</CategoryTxt>
        <Amt>7071</Amt>
        <NetInvestmentIncomeAmt>0</NetInvestmentIncomeAmt>
        <DisbursementsCharitablePrpsAmt>0</DisbursementsCharitablePrpsAmt>
      </TaxesDetail>
    </TaxesSchedule>
  </ReturnData>
</Return>