2024-10-21T10:03:32-05:00 2023-12-31 991856619 GRANT THORNTON ADVISORS LLC 757 THIRD AVENUE NEW YORK NY 10017 990 2023-01-01 463673346 SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE INC CO WEILL CORNEL SAND 2123278704 1300 YORK AVENUE NEW YORK NY 10065 PETER T MEINKE PHD DIRECTOR 6469626126 2024-10-21 1 1 X P00504182 2125429609 2023 2024-10-15 13:58:12Z X PETER T MEINKE PHD 1300 YORK AVENUE NEW YORK NY 10065 18703204 0 X TRITDI.ORG X 2013 DE THE SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC. WAS ORGANIZED AND IS OPERATED AS AN INDEPENDENT, NON-PROFIT CORPORATION, CONTROLLED BY LEADING NOT-FOR-PROFIT ACADEMIC, MEDICAL AND RESEARCH INSTITUTIONS, TO FURTHER AND IMPROVE HEALTH AND THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASE THROUGH FUTHERING AND IMPROVING TRANSLATIONAL RESEARCH, GENERATE INNOVATIVE PROOF-OF-CONCEPT STUDIES, AND ADVANCE THE SCIENTIFIC ACTIVITIES OF THE CONTROLLING INSTITUTIONS' (MEMORIAL SLOAN KETTERING CANCER CENTER, THE ROCKEFELLER UNIVERSITY AND WEILL CORNELL MEDICAL COLLEGE)FACULTY, FELLOWS AND STUDENTS IN ASPECTS OF TRANSLATIONAL RESEARCH, CHEMISTRY, PHARMACOLOGY, AND DRUG DISCOVERY. 9 9 37 0 0 0 0 0 16999291 18571887 34984 131317 0 0 17034275 18703204 0 0 0 0 6659333 7498439 0 0 0 10374942 11204765 17034275 18703204 0 0 8782111 7953486 8782111 7953486 0 0 X THE SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC. WAS ORGANIZED AND IS OPERATED AS AN INDEPENDENT, NON-PROFIT CORPORATION, CONTROLLED BY LEADING NOT-FOR-PROFIT ACADEMIC, MEDICAL AND RESEARCH INSTITUTIONS, TO FURTHER AND IMPROVE HEALTH AND THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASE THROUGH FUTHERING AND IMPROVING TRANSLATIONAL RESEARCH, GENERATE INNOVATIVE PROOF-OF-CONCEPT STUDIES, AND ADVANCE THE SCIENTIFIC ACTIVITIES OF THE CONTROLLING INSTITUTIONS' (MEMORIAL SLOAN KETTERING CANCER CENTER, THE ROCKEFELLER UNIVERSITY AND WEILL CORNELL MEDICAL COLLEGE)FACULTY, FELLOWS AND STUDENTS IN ASPECTS OF TRANSLATIONAL RESEARCH, CHEMISTRY, PHARMACOLOGY, AND DRUG DISCOVERY. 0 0 6145143 6513423 THE SANDERS TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, A PARTNERSHIP AMONG THREE WORLD-RENOWNED SCIENTIFIC AND MEDICAL INSTITUTIONS, WORKS TO MORE EFFECTIVELY DEVELOP THERAPEUTICS THAT ARISE FROM DISCOVERIES MADE IN BASIC SCIENCE LABS. WITH A FOCUS ON EARLY-STAGE DRUG DISCOVERY, THE INSTITUTE PROVIDES EXPERTISE IN MEDICINAL CHEMISTRY AND COMPOUND SCREENING, AND CONDUCTS PROOF OF CONCEPT STUDIES NEEDED TO DEMONSTRATE THAT DRUG CANDIDATES CAN SUCCESSFULLY ALTER THE COURSE OF A DISEASE. SPECIFIC RESEARCH PROJECTS FOCUS ON ALZHEIMERS DISEASE, SICKLE CELL, OSTEOPOROSIS, LYSOSOMAL, LIPID DEPOSITS, PARKINSON'S AND BASAL CELL CARCINOMA. 11376658 12058464 THE INSTITUTE FACILITATES MORE EFFICIENT SHARING OF CORE FACILITIES BETWEEN THE THREE PARTNER INSTITUTIONS AND FORMS INDUSTRY PARTNERSHIPS WITH PHARMACEUTICAL AND BIOTECH COMPANIES TO FURTHER ADVANCE DRUG RESEARCH. IT SEEKS TO CREATE INTELLECTUAL PROPERTY THAT CAN BE FURTHER DEVELOPED BY AN OPEN FIELD OF INDUSTRY COLLABORATORS. THE MAJORITY OF SUCH SERVICES RELATE TO MEDICINAL CHEMISTRY SUPPORT. 17521801 1 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 37 0 0 0 0 0 0 0 0 0 0 0 X 9 9 0 1 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 NY X SANDRA LORBER 6469626161 1230 YORK AVENUE NEW YORK NY 10065 ROBERT HARRINGTON MD EFFECTIVE 915 MEMBER OF THE BOARD OF DIR 0.00 X 0 1059593 8980 BARRY COLLER MD MEMBER OF THE BOARD OF DIR 0.00 X 0 700493 121428 RICHARD P LIFTON MDPHD MEMBER OF THE BOARD OF DIR 0.00 X 0 1271737 276499 CARL NATHAN MD MEMBER OF THE BOARD OF DIR 0.00 X 0 625799 65187 DAVID SCHEINBERG MD PHD MEMBER OF THE BOARD OF DIR 0.00 X 0 667389 68171 SELWYN VICKERS MD MEMBER OF THE BOARD OF DIR 0.00 X 0 5489537 70070 BARBARA HEMPSTEAD MD MEMBER OF THE BOARD OF DIR 0.00 X 0 735940 49371 NATHANIEL HEINTZ PHD MEMBER OF THE BOARD OF DIR 0.00 X 0 541112 132853 DEREK TAN PHD MEMBER OF THE BOARD OF DIR 0.00 X 0 478519 68171 FRANCIS LEES MD MEMBER OF THE BOARD OF DIR 1/1/23-9/14/23 0.00 X 0 1296545 82438 MICHAEL P VITALE TREASURER 0.00 X 0 514456 140790 PETER T MEINKE PHD DIRECTOR 40.00 X 609089 0 71657 MANUEL BACA VICE PRESIDENT,BIOLOGICS T 40.00 X 389711 0 72256 PAUL BALDERES SR. DIRECTOR 40.00 X 271591 0 60288 NIGEL LIVERTON PHD VICE PRESIDENT,CHEMISTRY 40.00 X 280923 0 69751 PATRICIA AHA VICE PRESIDENT, OPRATIONS 40.00 X 228289 0 56740 SANDRA LORBER VICE PRESIDENT,FINANCE 40.00 X 233289 0 45094 2012892 13381120 1459744 33 0 1 0 WUXI UNIT 10 11/F BLOCK B NEW TRADE PL SHATIN SHATIN HK 00000 PROFESSIONAL SERVICES 2421400 ABLEXIS LLC 533 AIRPORT BLVD SUITE 400 BURLINGAME CA 94010 PROFESSIONAL SERVICES 1000000 GENSCRIPTS 860 CENTENNIAL AVENUE PISCATAWAY NJ 08854 PROFESSIONAL SERVICES 330895 HITGEN NO 6 HUGIG 1ST EAST ROAD SHUANGLIU SICHUAN CH 00000 PROFESSIONAL SERVICES 329375 SINGLE CELL TECHMOLOGY 6276 SAND IGNACIO AVE STE E SAN JOSE NY 95119 PROFESSIONAL SERVICES 295800 9 REVENUE FROM COLLABORATION AGREEM 541700 12058464 12058464 REVENUE FROM AFFILIATION AGREEMEN 541700 6513423 6513423 18571887 131317 131317 18703204 18571887 0 131317 X 597153 183275 413878 4927041 4561694 365347 1550557 1410376 140181 423688 412076 11612 130252 130252 102000 102000 6510805 6510805 76963 75345 1618 743353 743353 1880408 1863893 16515 63903 63903 378458 378458 73288 73288 SCIENTIFIC MATERIALS 1146776 1146776 OTHER 98559 98559 18703204 17521801 1181403 0 4957706 5570402 1476803 1396089 4387776 3400781 837762 986995 1509840 0 8782111 7953486 4434242 5420818 4347869 2532668 8782111 7953486 X 0 0 8782111 7953486 0 0 X 1 X 1 X 1 0 X X 3 THE ROCKEFELLER UNIVERSITY 131624158 2 1 0 0 MEMORIAL SLOAN - KETTERING CANCER CENTER- 131624082 3 1 0 0 WEILL CORNELL MEDICAL COLLEGE 133017214 2 1 0 0 3 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 4387776 3400781 986995 986995 DUE TO WEILL CORNELL MEDICAL CENTER 2532668 2532668 X 18737612 34408 34408 18703204 0 18703204 18737612 34408 34408 18703204 0 18703204 PART X, LINE 2: INCOME TAXES U.S. GAAP REQUIRES THAT A TAX POSITION BE RECOGNIZED OR DERECOGNIZED BASED ON A "MORE LIKELY THAN NOT" THRESHOLD. THIS APPLIES TO POSITIONS TAKEN OR EXPECTED TO BE TAKEN IN A TAX RETURN. TDI DOES NOT BELIEVE ITS FINANCIAL STATEMENTS INCLUDE ANY UNCERTAIN TAX POSITIONS THAT WOULD HAVE A MATERIALLY ADVERSE EFFECT ON ITS FINANCIAL CONDITION. PART XI, LINE 2D - OTHER ADJUSTMENTS: ROCKEFELLER CONTRIBUTED SERVICES - $34,408 PART XII, LINE 2D - OTHER ADJUSTMENTS: ROCKEFELLER CONTRIBUTED SERVICES - $34,408 FORM 990 - PART X, LINE 25 THIS LINE CONSISTS OF: DUE TO WEILL CORNELL MEDICINE $2,532,668 EAST ASIA PROGRAM SERVICES SCIENTIFIC RESEARCH 2750975 0 0 0 0 0 0 2750975 0 2750975 0 0 0 0 0 0 X X X 0 0 0 0 0 0 0 0 0 SELWYN VICKERS MD MEMBER OF THE BOARD OF DIR 0 2987929 0 2458333 0 43275 0 26400 0 43670 0 5559607 0 0 RICHARD P LIFTON MDPHD MEMBER OF THE BOARD OF DIR 0 1104363 0 0 0 167374 0 56836 0 219663 0 1548236 0 0 FRANCIS LEES MD MEMBER OF THE BOARD OF DIR 1/1/23-9/ 0 382304 0 0 0 914241 0 32778 0 49660 0 1378983 0 0 ROBERT HARRINGTON MD EFFECTIVE 915 MEMBER OF THE BOARD OF DIR 0 370848 0 150000 0 538745 0 0 0 8980 0 1068573 0 0 BARRY COLLER MD MEMBER OF THE BOARD OF DIR 0 627818 0 0 0 72675 0 56727 0 64701 0 821921 0 0 BARBARA HEMPSTEAD MD MEMBER OF THE BOARD OF DIR 0 311940 0 0 0 424000 0 33990 0 15381 0 785311 0 0 DAVID SCHEINBERG MD PHD MEMBER OF THE BOARD OF DIR 0 653031 0 0 0 14358 0 26400 0 41771 0 735560 0 0 CARL NATHAN MD MEMBER OF THE BOARD OF DIR 0 499534 0 0 0 126265 0 32778 0 32409 0 690986 0 0 PETER T MEINKE PHD DIRECTOR 487182 0 121907 0 0 0 32778 0 38879 0 680746 0 0 0 NATHANIEL HEINTZ PHD MEMBER OF THE BOARD OF DIR 0 491578 0 0 0 49534 0 56707 0 76146 0 673965 0 0 MICHAEL P VITALE TREASURER 0 320796 0 25000 0 168660 0 56428 0 84362 0 655246 0 0 DEREK TAN PHD MEMBER OF THE BOARD OF DIR 0 476619 0 0 0 1900 0 26400 0 41771 0 546690 0 0 MANUEL BACA VICE PRESIDENT,BIOLOGICS T 314711 0 75000 0 0 0 33990 0 38266 0 461967 0 0 0 NIGEL LIVERTON PHD VICE PRESIDENT,CHEMISTRY 235941 0 44982 0 0 0 33990 0 35761 0 350674 0 0 0 PAUL BALDERES SR. DIRECTOR 237615 0 33976 0 0 0 32778 0 27510 0 331879 0 0 0 PATRICIA AHA VICE PRESIDENT, OPRATIONS 192870 0 35419 0 0 0 30188 0 26552 0 285029 0 0 0 SANDRA LORBER VICE PRESIDENT,FINANCE 197870 0 35419 0 0 0 31560 0 13534 0 278383 0 0 0 OFFICERS, DIRECTORS WAGES PAID BY RELATED ORGANIZATION TO THE TDI BOARD OF DIRECTORS ARE NOTE TIED INTO THEIR SERVICES AT TDI. THE BOARD MEMEBRS ACT IN A VOLUNATRY CAPACITY AT TDI. FORM 990, PART VI, SECTION A, LINE 3 AFFILIATED ORGANIZATIONS PERFORM VARIOUS ADMINISTRATIVE FUNCTIONS FOR TDI INCLUDING ACCOUNTING, PURCHASING AND TREASURY. FORM 990, PART VI, SECTION B, LINE 11B ALL BOARD MEMBERS RECEIVE A COPY OF FORM 990 TWO WEEKS IN ADVANCE OF ITS FILING. BOARD MEMBERS ARE ENCOURAGED TO CONTACT MANAGEMENT IF THEY HAVE ANY QUESTIONS. FORM 990, PART VI, SECTION B, LINE 12C OFFICERS, DIRECTORS OR TRUSTEES SUBMIT ANNUAL CONFLICT OF INTEREST QUESTIONNAIRES TO MANAGEMENT. FORM 990, PART VI, SECTION B, LINE 15 COMPENSATION FOR THE DIRECTOR IS ESTABLISHED AND APPROVED BY THE BOARD. SUCH COMPENSATION IS ESTABLISHED THROUGH REVIEW OF COMPARABILITY DATA AND CONTEMPORANEOUS SUBSTANTIATION OF THE DELIBERATION AND DECISION. SPECIFIC REVIEWS OCCUR ON AN ANNUAL BASIS. A STAFF SECONDMENT AGREEMENT WAS ENTERED INTO ON JULY 6, 2014 BETWEEN CORNELL UNIVERSITY ON BEHALF OF ITS WEILL CORNELL MEDICAL COLLEGE (WCMC) AND TDI. THE AGREEMENT STATES THAT WCMC WILL PROVIDE SECONDED EMPLOYEES TO TDI. THE AGREEMENT FURTHER STATES THAT WCMC WILL PROVIDE ALL SALARIES AND BENEFITS TO ALL SECONDED EMPLOYEE AND BE RESPONSIBLE FOR ALL TAX REPORTING AND WITHHOLDINGS. IN TURN, TDI AGREES TO REIMBURSE WCMC FOR ALL RELATED EMPLOYMENT COSTS. THE TERM OF THE AGREEMENT IS ONE YEAR EXPIRING ON JUNE 30, 2015, AND SHALL BE RENEWED THEREAFTER FOR SUCCESSIVE ONE YEAR TERMS UNLESS IT IS TERMINATED BY EITHER PARTY. AN UPDATED AGREEMENT WAS SIGNED AND EXPIRES ON DECEMBER 31, 2023. TDI HAD 37 SECONDED EMPLOYEES IN 2023. FORM 990, PART VI, SECTION C, LINE 19 CONFLICT OF INTEREST POLICIES ARE MADE AVAILABLE THROUGH THE WEILL CORNELL MEDICAL COLLEGE'S WEB SITE. FORM 990, PART VI, SECTION B. POLICIES, LINE 12C TDI HAS ADOPTED A FORMAL CONFLICT OF INTEREST POLICY IN ORDER TO PROTECT THE INTEREST OF TDI WHEN IT IS CONTEMPLATING ENTERING INTO A TRANSACTION OR ARRANGEMENT WHERE THE FINANCIAL INTERESTS OF AN OFFICER OR DIRECTOR OF THE INSTITUTE MAY DIVERGE FROM THE INTERESTS OF THE INSTITUTE. ON AN ANNUAL BASIS, EACH DIRECTOR AND OFFICER SHALL SIGN A STATEMENT WHICH AFFIRMS SUCH PERSON: A. HAS RECEIVED A COPY OF THE CONFLICT OF INTEREST POLICY; B. HAS READ AND UNDERSTANDS THE POLICY; C. HAS AGREED TO COMPLY WITH THE POLICY, AND D. UNDERSTANDS THE INSTITUTE IS CHARITABLE AND IN ORDER TO MAINTAIN ITS FEDERAL TAX EXEMPTION IT MUST ENGAGE PRIMARILY IN ACTIVITIES WHICH ACCOMPLISH ONE OF MORE OF ITS TAX-EXEMPT PURPOSES. THE TDI BY-LAWS STATE THAT THE BOARD CONSIST OF A MINIMUM TOTAL OF TWO DIRECTORS FROM EACH FOUNDING INSTITUTION, FOR A TOTAL OF NINE DIRECTORS; NONE OF WHOM HAD A BUSINESS RELATIONSHIP OUTSIDE OF THEIR OWN INSTITUTION. FORM 990, PART IX, LINE 11G CHEMISTRY SUPPORT: PROGRAM SERVICE EXPENSES 6,510,805. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 6,510,805.