2023-09-13T10:01:53-07:00 2022-12-31 410746749 CliftonLarsonAllen LLP 220 S 6th Street Suite 300 Minneapolis MN 55402 990 2022-01-01 411717098 AMERICAN BRAIN FOUNDATION AMER 6129286300 201 Chicago Avenue Minneapolis MN 55415 Jane Ransom Executive Director 6129286317 2023-09-13 1 1 Sarah Reichling P01587996 6123973066 2023-09-13 1 11 1 AAL2 2022 2023-04-26 12:10:37Z Jane Ransom 201 Chicago Ave Minneapolis MN 55415 8944650 0 X www.americanbrainfoundation.org X 1992 MN The mission of the American Brain Foundation is to accelerate breakthrough research on brain disease and optimize brain health for all. We are passionate about our mission and believe that our vision of Life Without Brain Disease can be attained. The foundation enjoys a close research partnership with our primary partner, the American Academy of Neurology. The Academy's Science Committee is responsible for vetting all of the research grants we make, assuring that fund the best and brightest scientists. Our motto is Cure One, Cure Many. Driven by the certainty that brain diseases are interconnected, our foundation invests in research on mechanisms shared by multiple brain diseases and conditions, setting the stage for new treatments for diseases that were previously untreatable to emerge. To assure that the discoveries generated from research investments are developed and extended into the future, identifying and funding the best researchers is a high priority. 15 15 9 15 0 0 6035920 6002262 0 0 2901992 54689 -55702 -110178 8882210 5946773 2245973 5297664 0 0 1080361 1237544 7508 0 632720 1144194 1178443 4478036 7713651 4404174 -1766878 18178228 16866097 1651520 3676391 16526708 13189706 The mission of the American Brain Foundation is to accelerate breakthrough research across all brain diseases and optimize brain health for all. We are passionate about our mission and believe that our vision of Life Without Brain Disease can be attained. Our motto is Cure One, Cure Many. Driven by the certainty that brain diseases are interconnected, our foundation invests in research on mechanisms shared by multiple brain diseases and conditions, setting the stage for new treatments for diseases that were previously untreatable to emerge. 0 0 5300501 5105575 0 GRANTS: In 2022, the American Brain Foundation funded Next Generation Research grants in Amyotrophic Lateral Sclerosis (ALS); Alzheimer's; Cognitive Aging and Age-Related Memory Loss; Epilepsy; Frontotemporal Degeneration; Lewy-Body Dementia; Multiple Sclerosis; Muscular Dystrophy; Neuromuscular Disease; Parkinson's Disease; Stroke; and Tourette Syndrome. These are two-year clinical innovative research projects that launch the research of early-career investigators. Over 80% of the nearly 300 researchers the foundation has funded have received additional research funding from the NIH and other entities to continue the research started with our grants. Also in 2022, the Amreican Brain Foundation funded a seed grant in autism to promote diversity, equity, and inclusion in autism research. Finally in 2022, the American Brain Foundation led in the development and funding of an initiative to find a biomarker for the early diagnosis of Lewy body dementia with partners the Alzheimer's Association, the Michael J. Fox Foundation, and the American Academy of Neurology. We expect this research to lead to more clarity and effective therapies for people struggling with LBD, and to increase our understanding of other neurodegenerative brain diseases, such as Alzheimer's disease and Parkinson's disease. 248449 192094 0 AWARDS: The American Brain Foundation honored and provided financial support to leaders in the fight against brain disease-both scientists and members of the public. Among these were the internationally known Potamkin Prize in Pick's, Alzheimer's, and related diseases, and the Sheila Essey Award for Research in ALS. Other awards included: PUBLIC LEADERSHIP IN NEUROLOGY AWARD: The award honors an individual or group outside of the medical profession known for advancing public understanding and awareness of neurological disease, being effective advocates for neuroscience research, and making significant contributions to improve patient care. Seth Rogen and Lauren Miller Rogen received the 2022 award for their role in supporting families dealing with dementia, educating young people about living a brain-healthy life, and inspiring the next generation of Alzheimer's advocates and researchers. SCIENTIFIC BREAKTHROUGH AWARD: This award honors a scientist or team of scientists responsible for a significant research breakthrough in preventing, curing, or treating a brain disease or disorder. The 2022 recipient was Dr. Stephen Hauser, MD. Dr. Hauser's research has advanced our understanding of the genetic basis, immune mechanisms, and treatment of multiple sclerosis (MS). His work led to the development of B cell therapies for MS patients, representing a powerful new approach for relapsing forms of the disease. His 40+ year, career-long commitment has changed the landscape of treatment for what has been, until now, a relentlessly progressive form of MS. ASSOCIATION OF INDIAN NEUROLOGISTS IN AMERICA LIFETIME ACHIEVEMENT AWARD: This award is given to a North American neurologist dedicated to advancing the training of North American neurologists of Indian origin and promoting innovation and research in the field of neurology. The 2022 recipient was Dr. Aneesh Singhal, MD, FAAN. MRIDHA SPIRIT OF NEUROLOGY AWARD: This humanitarian award recognizes neurologists or neuroscientists who have served a distressed, destitute, or marginalized population, or have provided care in impoverished communities of the world. The 2022 recipients were Dr. Bindu Menon, MD, DM, DNB, PGDCN, FRCP, MNAMS, FICP, FIAN, FWSO and Dr. Bruce Ovbiagele, MD, MSc, MAS, MBA, FAAN. TED BURNS HUMANISM IN NEUROLOGY AWARD: This award aims to celebrate neurologists whose work embodies humanism in patient care, education, advocacy, and everyday encounters. The 2022 recipient was Dr. Barbara S. Giesser, MD, FAAN. AMERICAN ACADEMY OF NEUROLOGY SCIENTIFIC AWARDS: The American Brain Foundation underwrote the American Academy of Neurology's prestigious scientific awards including the Dreifuss-Penry Epilepsy Award, Norman Geschwind Prize in Behavioral Neurology, Mitchell B. Max Award for Neuropathic Pain, Movement Disorders Research Award, Michael S. Pessin Stroke Leadership Prize, Sleep Science Award, Jon Stolk Award in Movement Disorders for Young Investigators, Founders Award, S. Weir Mitchell Award, Neuro-oncology Scientific Award, Neuroinfectious Disease Award, Kenneth M. Viste Jr, MD, Patient Advocate of the Year Award, Bruce S. Schoenberg Award, Harold Wolff-John Graham Award, Wayne A. Hening Sleep Medicine Investigator Award. 826903 0 0 PUBLIC OUTREACH: The American Brain Foundation continued to invest in a large-scale public awareness campaign with the purpose of educating the public about the need for brain disease research. The multi-channel campaign provided resources and information about brain diseases and disorders, the latest brain research news, and stories from patients and caregivers. The American Brain Foundation produced free monthly webinars with neurology experts for the public on topics such as Deep Brain Stimulation, Sleep and the Brain, and Migraine Research and Treatment. The Commitment to Cures gala was a hybrid event and was attended by nearly 2,000 people and raised over $850,000. All key performance indicators for public outreach exceeded goals. Comparing 2022 to 2021, Social media followers increased 51%, website traffic increased 50%, and email subscribers increased 31%. 0 0 0 6375853 1 1 0 0 0 1 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 9 0 1 9 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 X 15 15 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 0 0 AK AL AR CA CO CT DC FL GA HI IL KS KY MA MD ME MI MN MO MS NC ND NH NJ NM NV NY OH OK OR PA RI SC TN UT VA WA WI WV X X Kevin Myren 6129286023 201 Chicago Avenue Minneapolis MN 55415 JANE RANSOM EXECUTIVE DIRECTOR 41 X 308660 0 46395 EMILY CHRISTIAN DEPUTY DIRECTOR 40 X 144769 0 21630 DAVID D DODICK CHAIR 1.5 X X 0 0 0 BEN LENAIL VICE CHAIR 1 X X 0 0 0 JAMES ESSEY TREASURER 1 X X 0 0 0 JACQUELINE FRENCH SECRETARY 1 X X 0 0 0 ORLY AVITZUR EX OFFICIO VOTING DIRECTOR 0.50 X X 0 0 0 ROBERT C GRIGGS EX OFFICIO VOTING DIRECTOR 0.50 X X 0 0 0 MERIT CUDKOWICZ DIRECTOR 0.5 X 0 0 0 DAVID EAGLEMAN DIRECTOR 0.50 X 0 0 0 DAN GASBY DIRECTOR 0.50 X 0 0 0 JAMES C GROTTA DIRECTOR 0.5 X 0 0 0 FRANCES JENSEN DIRECTOR 0.5 X 0 0 0 RALPH LESILE DIRECTOR 0.50 X 0 0 0 RONALD PETERSEN DIRECTOR 0.50 X 0 0 0 ALYX B PORTER DIRECTOR 0.50 X 0 0 0 SEAN SANSIVERI DIRECTOR 0.5 X 0 0 0 MARY E POST EX OFFICIO NON-VOTING DIRECTOR 0.50 X 0 0 0 453429 0 68025 2 0 1 0 Yakkety Yak 216 S Jefferson St Suite 200 Chicago IL 60661 Full service digital marketing agency 470440 American Academy of Neurology 201 Chicago Avenue Minneapolis MN 55415 Management Services & Occupancy 211435 2 0 0 662985 0 0 5339277 0 6002262 0 0 0 0 0 193526 0 0 193526 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2715957 0 2854794 0 -138837 0 -138837 0 0 -138837 32200 662985 143083 -110883 0 -110883 0 0 0 0 0 0 0 0 0 0 0 0 Miscellaneous Income 900099 705 0 0 705 0 0 0 0 705 5946773 0 0 -55489 5296664 5296664 1000 1000 0 0 0 0 355055 127820 134921 92314 0 0 0 0 663086 238711 251973 172402 62238 22405 23651 16182 93589 33692 35564 24333 63576 22887 24159 16530 55628 20969 20013 14646 14252 896 10516 2840 125844 42322 53962 29560 0 0 0 0 0 0 8951 0 8951 0 490842 373717 14347 102778 85524 84735 0 789 230634 35159 78700 116775 31924 12034 11485 8405 0 0 0 0 36991 13210 14554 9227 42319 21622 8680 12017 0 0 0 0 25616 14583 1622 9411 0 0 0 0 0 0 0 0 12449 12449 0 0 9198 0 9198 0 Miscellaneous Expense 8271 978 2782 4511 7713651 6375853 705078 632720 653804 1460384 2018103 2274246 4158026 3281095 66746 321854 0 0 0 0 0 0 0 0 38631 55090 213045 213045 12450 0 11230468 9473428 0 0 0 0 0 0 0 0 18178228 16866097 154343 232951 1492927 3438245 4250 5195 0 0 0 0 0 0 0 0 0 0 0 0 1651520 3676391 X 5880256 6350103 10646452 6839603 16526708 13189706 18178228 16866097 -1766878 -1570124 0 0 0 0 X 0 1 1 0 X 3122906 4703334 5675913 6035920 6002262 25540335 0 0 0 0 0 0 0 0 0 0 0 0 3122906 4703334 5675913 6035920 6002262 25540335 5817878 19722457 282695 249969 233645 441373 162383 1370065 0 0 0 0 0 0 0 0 0 0 0 0 26910400 0 0.73289 0.66760 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 3 0 14436 0 243781 0 21086 0 1 1 4888032 10401 -653510 85470 0 31288 4128165 4028837 380695 597232 88190 0 30540 4888034 3784027 78271 269623 91480 0 11604 4028837 2967570 340366 557165 81076 0 0 3784025 2864075 421372 -247129 70748 0 0 2967570 0 0.7172 0.2828 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 213045 213045 0 0 0 0 X 5115517 -1570124 595785 0 143083 -831256 5946773 0 0 0 5946773 8452519 595785 0 0 143083 738868 7713651 0 0 0 7713651 Schedule D, Part V, Line 4 A portion of interest earned on endowment funds is recorded as temporary restricted funds and used to support awards and clinical research training scholarships Schedule D, Part X, Line 2 The Organization follows the provisions of FASB ASC 740.10.2s, which requires that a tax position be recognized or derecognized based on a "more likely than no" threshold. This applies to positions taken or expected to be taken in a tax return. The Organization does not believe its financial statements include any uncertain tax positions. The Organizations tax returns are subject to review and examination by federal authorities Schedule D, Part XI, Line 2d Fundraising event expenses netted out on Schedule VIII from the Commitment to Cures gala. Schedule D, Part XII, Line 2d Fundraising event expenses netted out on Schedule VIII from the Commitment to Cures gala. 2022 Commitment to Cures Gala 695185 662985 32200 0 0 27684 58962 1200 55237 0 0 695185 662985 32200 0 0 27684 58962 1200 55237 143083 -110883 1 American Academy of Neurology Institute 201 Chicago Avenue Minneapolis MN 55415 410726167 3 5493094 0 Clinical Research Training Scholarships, Scientific Awards, and Non-scientific Awards for work on diseases of the brain and nervous system. See Part IV for more details. National Multiple Sclerosis Society 733 3rd Avenue Third Floor New York NY 10017 135661953 3 75000 0 Clinician Scientist Development Award in Multiple Sclerosis Hilarity for Charity 9301 Wilshire Blvd Suite 507 Beverly Hills CA 90210 822316072 3 10000 0 Public Leadership in Neurology Award 3 0 Schedule I, Part I, Line 2 The American Brain Foundation's (ABF) Next Generation Research Grants program funds Clinical Research Training Scholarships (CRTS) and Clinician Scientist Development Awards (CSDA) offered to neurologists and clinical investigators interested in academic careers in clinical research on brain diseases and disorders. More than 80 percent of the recipients of these ABF-funded awards have gone on to receive funding from NIH, enabling a lifetime of research on brain disease. The ABF awards grant funding to the research programs of the American Academy of Neurology, the National Multiple Sclerosis Society, and other institutions who regrant funds to early career investigators through their institutions. The administering institutions report progress annually back to the ABF. Schedule I, Part II, Line 1 Further elaboration for the $5.493M to the AANI in 2022: $3.015M of those funds were distributed for the American Brain Foundation's 2022 Cure One, Cure Many Award: A research award for early diagnosis for Lewy Body Dementia. $2.245M of these funds were distributed to fulfill grants in the following categories: Clinical Research Training Scholarship in ALS, Richard Olney Clinician Scientist Development Award in ALS, Clinical Research Training Scholarship in Alzheimer's or related disorders research, McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age Related Memory Loss, Susan S. Spencer, MD Clinical Research Training Scholarship in Epilepsy, Clinical Research Training Scholarship in Frontotemporal Degeneration, Clinical Research Training Scholarship in Lewy Body Diseases, Clinical Research Training Scholarship in Muscular Dystrophy, Clinical Research Training Scholarship in Neuromuscular Disease, Clinical Research Training Scholarship in Parkinson's Disease, Clinical Research Training Scholarship in Stroke, Clinical Research Training Scholarship in Tourette Syndrome. $178K of the funds to AANI were distributed to neurologists for Scientific Awards in the following categories: Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, Sheila Essey Award: An Award for ALS Research, Neuro-lnfectious Disease Award, Alliance Awards: Founders, Alliance Awards: S. Weir Mitchell, Dreifuss-Penry Epilepsy Award, Harold Wolff-John Graham Award, Jon Stolk Award in Movement Disorders for Young Investigators, Michael S. Pessin Stroke Leadership Prize, Mitchell B. Max Award for Neuropathic Pain, Movement Disorders Research Award, Neuro-Oncology Scientific Award, Norman Geschwind Prize in Behavioral Neurology, Sleep Science Award, Wayne A. Hening Sleep Medicine Investigator Award, Bruce S. Schoenberg Award, Cheryl A. Jay Lectureship, and George C. Cotzias Lecture Award. $55K of these funds were distributed as a seed grant in Autism. X X X X 0 0 0 0 0 0 0 0 0 JANE RANSOM EXECUTIVE DIRECTOR 267213 0 40943 0 504 0 28819 0 17576 0 355055 0 33943 0 EMILY CHRISTIAN DEPUTY DIRECTOR 127485 0 16780 0 504 0 13300 0 8330 0 166399 0 9866 0 Schedule J, Part I, Line 3 The American Brain Foundation leases employees with American Academy of Neurology (AAN) through a contractual arrangement by which AAN's employees are leased to ABF. This arrangement included, as of 2022, the ABF's Executive Director being leased through AAN. The ABF's Board of Directors is responsible for hiring and setting the compensation for the Executive Director. The Board employs procedures (use of independent consultant, compensation survey and no involvement of persons with conflicts of interests) and last set compensation amounts in 2022. Form 990, Part VI, Section B, Line 11b The CFO undertook extensive review of the draft form 990 as initially prepared by the Staff Accountant. Their review was thereafter augmented by exempt organizations tax/legal counsel and an external audit firm. This Form 990 was then presented to the Audit Committee by the CFO and other members of the management team. The Audit Committee Reviewed the Form 990 and identified any agreed upon changes to be made. In line with Minnesota Law, the final Form 990 is presented to and approved by the Board of directors. The Form 990 is filed subsequent to this process. Form 990, Part VI, Section B, Line 12c The Foundation's conflict of interest policy covers individuals serving as an officer, director, committee member, or positions of official responsibility or leadership. All covered are required to complete a relationship disclosure statement annually, or as changed in personal circumstances occur. The statements are reviewed and actions determined according to the Foundation's hierarchy based on position or by the Executive Committee if a resolution cannot be made. Potential conflicts are handled on an individual basis. Actions taken depend on the severity of the conflict which include no action required, on-going monitoring with appropriate disclosure or withdrawal from the conflicting relationship. Conflict of interest proceeding are documented in meeting minutes or as appropriate Form 990, Part VI, Section B, Line 15 The American Brain Foundation leases all employees from the American Academy of Neurology (AAN) through a contractual arrangement. This arrangement included, as of 2022, the Foundation Executive Director being leased through AAN. The ABF's Board of Directors is responsible for hiring and setting the compensation for the Executive Director. The Board employs procedures (use of independent consultant, compensation survey, and no involvement of any persons with conflict of interest) and last set compensation amounts in 2022 Form 990, Part VI, Section C, Line 19 The Foundation makes the most recent three years audited financial statements and IRS Form 990 available to the public on its website. The Foundation does not make its other governing documents (e.g. articles of incorporation) nor its Conflict of Interest policy available to the public.