2023-05-04T15:00:33-07:00 2022-12-31 990 2022-01-01 473425850 CANCER PREVENTION INITIATIVE INC CANC 8444374891 1722 Routh Street Suite 770 Dallas TX 75201 Theodora Ross President 8444374891 2023-05-04 1 1 11 1 AAL2 X 2022 2023-04-26 12:10:37Z Theodora Ross 2555 N Pearl St Unit 804 Dallas TX 75201 257068 0 X www.cancerpreventioninitiative.org X 2015 DE Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. 6 6 0 6 0 0 135 245219 0 0 16 11849 0 0 151 257068 215236 0 0 0 49916 0 0 0 0 42890 18418 308042 18418 -307891 238650 962671 1056196 501296 356171 461375 700025 Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. CPI uses its research, medical and pharmaceutical expertise to invest in first-rate science that will discover new strategies for preventing cancer. Our strategy is to support research on prevention of inherited cancers as a path towards elimination of all cancers. CPI acts as a facilitator to ensure that good ideas can find sufficient funding to turn them into therapeutic solutions such as drugs or vaccines to prevent cancer. CPI provides financial support, guidance and expertise throughout the research and development process to help researchers use the resources (donations) for the highest possible impact. 0 0 5517 0 0 In 2022, the Cancer Prevention Initiative (CPI) research programs progressed, and CPI continued to grow and develop. The CPI scientific team continued to monitor and support scientific progress on multi-year programs. CPI's research grant recipients have advanced towards greater understanding of preventing inherited cancers. Ongoing projects include Cleveland Clinic, where investigators seek to identify proteins uniquely and highly expressed in breast cancer of BRCA1 mutation carriers. Identification of these unique proteins is an important link for developing preventative vaccines. Also continuing is a project with Memorial Sloan Kettering Cancer Center to generate a robust cellular assay that would allow for the screening of hundreds of compounds to identify determinants of Loss of Heterozygosity (LoH) of BRCA genes. LoH is a major driver in cancer initiation, and discovery of compounds that cause LoH can be key for prevention discoveries. Other ongoing projects include Harvard's Beth Israel Deaconess Medical Center where they are working to identify cancer risk predictors in the reproductive epithelium in BRCA mutation carriers, and work at the University of Toronto to screen for drugs that can restore normal BRCA1 function to BRCA1 deficient cells. An international collaboration has co-developed a candidate vaccine for the prevention of triple negative breast cancers in patients who have inherited a BRCA1 mutation. 0 0 0 Education and community engagement programs: As we move closer to our goal of eradicating all cancers through preventative medicines, we believe that educating the public and raising awareness about inherited cancer syndromes will inspire more individuals to take proactive, life-saving preventive measures. One of the goals is to enhance the scientific reach of the organization and raise awareness on cancer prevention to a broader audience of patients, advocates and donors. Thus, regular updates on scientific and medical research advances, recent clinical trials, and interviews with experts in cancer prevention are published on web-based platforms. We also conduct an annual scientific symposium with all the researchers we fund and other scientists working on cancer prevention. 0 0 0 5517 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 X 6 6 0 0 0 0 0 0 0 1 0 0 0 1 1 1 1 1 1 0 0 0 CA CO CT FL IL KS NJ NY PA X Archer Accountancy Group 8444374891 6475 East Pacific Coast Hwy Suite 343 Long Beach CA 90803 X Theodora Ross President & Chief Scientific Officer 10 0 X X 0 0 0 Howard Janzen Board Chair; Chief Financial Officer 3 0 X X 0 0 0 Kirk Patrick Secretary, Trustee 0.5 0 X X 0 0 0 Jan Livingston-Mokhtari Trustee 0.5 0 X 0 0 0 Douglas Hager Trustee, Sr. Vice President, Project Management and Operations 10 0 X 0 0 0 Joi Morris Trustee 5 0 X 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 245219 0 245219 0 11849 11849 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 257068 11849 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2375 0 2375 0 0 0 0 0 0 0 -13 0 -13 0 0 0 0 0 0 0 0 0 3367 0 3367 0 5837 5517 320 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3590 0 3590 0 2405 0 2405 0 Bank Charges 13 0 13 0 Fees & Licenses 844 0 844 0 0 0 0 0 18418 5517 12901 0 3894 1165 82786 14413 25000 0 0 0 0 0 0 0 0 0 0 0 6414 6676 0 832402 1025357 0 0 0 0 12175 8585 0 0 962671 1056196 938 93 500358 356078 0 0 0 0 0 0 0 0 0 0 0 0 0 501296 356171 X 171611 235261 289764 464764 461375 700025 962671 1056196 238650 0 0 0 0 0 X 0 0 0 X 1210400 248799 480096 135 245219 2184649 0 0 0 0 0 0 1210400 248799 480096 135 245219 2184649 1489361 695288 13828 48611 1695 16 11849 75999 0 0 0 0 0 0 0 0 0 0 0 0 2260648 0 0.30756 0.35336 X Form 990, Part VI, Section A, Line 8b Governing body has no committees with authority to act on behalf of the board. Form 990, Part VI, Section B, Line 11b All members of the governing body receive a copy of the 990 prior to filing, with the opportunity for input and questions. Form 990, Part VI, Section B, Line 12c The Board of Trustees annually reviews the Conflict of Interest policy and each covered person is annually required to sign a statement that discloses all potential conflicts of interest and affirms that such person: 1. Has received a copy of the Conflict of Interest Policy; 2. Has read and understands the Conflict of Interest policy; 3. Has agreed to comply with the Conflict of Interest Policy; 4. Understands that CPI is a charitable organization and that in order to maintain its federal tax exemption and the trust of the public it must diligently avoid conflicts of interest or the appearance of any conflict of interest and engage primarily in activities that accomplish one or more of its tax exempt purposes. Form 990, Part VI, Section C, Line 19 The organization complies with IRS Section 6104 regarding public disclosure. As such, our annual information returns, conflict of interest policy, audited financial reports, and governing documents are available for public inspection upon request.